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Table 5 Experiment 2: Concentrations of prostaglandin E 2 , leukotriene B 4 , thromboxane B 2 and 8-isoprostane measured in lung perfusate samples collected at the end of MV

From: The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury

 

Air

Acid

Mediator (pg/ml)

No treatment

bLES

No treatment

bLES

Prostaglandin E2

14.3 ± 2.0

26.8 ± 3.9

147.4 ± 40.3

221.7 ± 89.2*

Leukotriene B4

14.4 ± 5.2

10.6 ± 5.3

13.1 ± 7.3

41.9 ± 12.3

Thromboxane B2

52.7 ± 10.1

67.8 ± 12.9

109.9 ± 24.8

134.9 ± 43.6

8-Isoprostane

11.3 ± 1.6

19.7 ± 3.0

47.2 ± 8.1*

70.4 ± 12.5*

  1. Data are expressed as mean ± SEM; n = 6 per group. *p < 0.05 versus the respective Air control.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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