Figure 1From: The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods The COCOA study is designed to investigate the causal contribution of the following five environmental interventions to the development and natural course of allergic diseases: (1) perinatal exposure to indoor factors (namely, house-dust mites, bacterial endotoxins, tobacco smoking, and particulate matter 2.5 and 10), (2) perinatal exposure to outdoor pollutants, (3) perinatal maternal psychosocial stress, (4) perinatal nutrition, and (5) the perinatal microbiome. Back to article page