Lung transplantation in idiopathic pulmonary fibrosis: a systematic review of the literature

Kistler, Kristin D; Nalysnyk, Luba; Rotella, Philip; Esser, Dirk

doi:10.1186/1471-2466-14-139

BMC Pulmonary Medicine

Table 1 Summary of post-transplantation survival among patients with IPF

From: Lung transplantation in idiopathic pulmonary fibrosis: a systematic review of the literature

Data source	Yr. of transplant	No. of IPF patients	% of patients alive (95% confidence interval)
Data source	Yr. of transplant	No. of IPF patients	3 mo.	1 yr.	3 yr.	5 yr.	10 yr.
*ISHLT data*
ISHLT website & ISHLT 2012 Annual Report [12, 18]	1990 – 2011	8,528	85	75	59	47	24
*OPTN data*
OPTN website [19]	1997 – 2004^a	1,271^b	NR	80 (77, 83)	57 (53, 61)	41 (36, 44)	NR
2011 Annual Report [11]	2005 – 2006	755	91	81	64	53	NR
Analysis of OPTN data (Meyer, et al) [20]	1988 – 1997	NR	NR	NR	NR	32.1 ± 2.4% (mean±SE)	NR
Analysis of OPTN data (Thabut, et al) [21]	1987 – 2009	3,327	NR	76 (75, 78)	59 (57, 61)	44 (42, 46)	NR
Analysis of OPTN data (Edwards, et al)[22]	1996 – 2001	786	NR	~68^c	~50^c	~39^c	NR
Analysis of OPTN data (McCurry, et al) [23]	2001 – 2006	1,636	NR	NR	NR	49	NR
Analysis of OPTN data (Chen, et al) [24]	2002 – 2005	1,418	NR	~79 (~75, ~82)^c	NR	NR	NR
Analysis of OPTN data (Chen, et al) [24]	2005 – 2008	1,563	NR	~80 (~78, ~83)^c	NR	NR	NR
Analysis of OPTN data (Freitas, et al) [25]	1987 – 2009	4,205	NR	77^d	58^d	44^d	NR
OPTN and Loyola University Medical Center databases [26]	1991 – 2009	4,190	NR	78	61	47	NR
*Other registries and large databases*
Spanish Lung Transplant Registry (Coll, et al) [27]	2006 – 2010	261	~80^c	~63^c	NR	NR	NR
Nationwide Inpatient Sample, US (Teo, et al) [28]	1988 – 2006	231	In-hospital: 91	NR	NR	NR	NR
*Single center studies in Europe, Brazil and Australia*
Single center in Denmark (Burton, et al) [29]	1992 – 2004	21	76	NR	52	NR
Inova Fairfax Hospital Interstitial Lung Disease Clinic, England (Nathan, et al) [30, 31]	2000 – 2009	84	NR	83	61	41	NR
	1996 – 2002	23	95.7	NR	NR	NR	NR
Papworth Hospital, England (McNeil, et al) [32]	1984 – 1994	11	46	NR	NR	NR	NR
Hopital Beaujon, France (Thabut, et al) [33]	1988 – 2001	28	30 day: 93	79	2 yr: 64	39	NR
University of Munich, Germany (Neurohr, et al) [34]	1997 – 2008	76	87	74	65	53	7.5 yrs: 40
University of Cordoba, Spain (Algar, et al) [35]	1993 – 2009	89	NR	53	40	33
Santa Casa de Misericordia de Porto Alegre, Brazil (Machuca, et al) [36]	2004 – 2009	53	NR	72	NR	NR	NR
Alfred Hospital, Melbourne, Australia (Keating, et al) [37]	1990 – 2008	67	NR	76	NR	50	34
*Single center studies in North America*
University of Pittsburgh, US (DiGiuseppe, et al) [38]	1986 – 2007	78		NR	NR	50	~32^c
Two centers (Johns Hopkins Hospital and the University of Pittsburgh Medical Center), US (Schachna, et al) [39]	1989 – 2002	70	6-month: 80	2-year: 67	NR	NR	NR
University of Pennsylvania, US (Rivera-Lebron, et al) [40]	2005 – 2010	68	NR	78	NR	52	NR
Washington University School of Medicine, St Louis, Mo, US (Meyers, et al) [41]	1988 –1998	45	NR	76	NR	54	NR
University of California, Los Angeles, US (Saggar, et al) [42]	2003 – 2007	38	NR	87	NR	NR	NR
Vanderbilt University Medical Center, US (Milstone, et al) [43]	1990 – 1998	32	NR	25	NR	NR	NR
University of Virginia, US (Smith, et al) [44]	1995 – 2005	27	30 day: <60 yrs: 100; ≥60 yrs: 93 (79, 100)	<60 yrs: 85 (65, 100) ≥ 60 yrs: 93 (79, 100)	<60 yrs: 68 (42, 94) ≥ 60 yrs: 93 (79, 100)	<60 yrs: 48 (19, 78) ≥60 yrs: 58 (26, 90)	NR
University of Alabama, US (Wille, et al) [45]	1994 – 2004	48	87	80	67	47	NR
Washington University/Barnes Hospital (Davis, et al) [46]	1998 – 1993	16	In-hospital: 87	72	62	NR	NR
Toronto Lung Transplant Group, Canada (Grossman, et al) [47]	1983 – 1989	16	NR	63	NR	NR	NR
Cleveland Clinic, US (Mason, et al) [48]	1990 – 2005	82	30-day: 95	73	56	44	7-year: 36
University of Wisconsin Hospital and Clinics (De Oliviera, et al) [49, 50]	1993 – 2009	79	In-hospital: 94	82	63	63	NR

^a 1-year survival based on 2002 – 2004 transplants, 3-year survival based on 1999 – 2002 transplants, 5-year survival based on 1997 – 2000 transplants.
^b Denominator gotten from http://optn.transplant.hrsa.gov/latestData/rptData.asp.
^c Percent is estimated based on graphical display of data.
^d Graft survival.

Back to article page

ISSN: 1471-2466

Contact us

Submission enquiries: bmcpulmonarymedicine@biomedcentral.com
General enquiries: ORSupport@springernature.com