Table 6 Comparisons of pro-inflammatory and anti-inflammatory cytokines in BALF and blood between survivors and non-survivors of pure PJP patients
Survivor (N =28) | Non-survivor (N =19) | P value* | P value# | |
|---|---|---|---|---|
BALF | ||||
IL-1β, pg/ml | 2.21(1.68;3.51) | 2.00(1.50;2.91) | 0.948 | |
TNF-α, pg/ml | 10.07(7.98;14.05) | 10.10(9.07;11.60) | 0.761 | |
IL-8, pg/ml | 35.63(22.60;79.26) | 114.80(36.70;375.60) | 0.010 | 0.694 |
IL-17, pg/ml | 15.00(15.00;15.00) | 15.00(15.00;15.00) | 0.751 | |
MCP-1, pg/ml | 736.49(218.78;2703.81) | 1065.50(344.00;3069.70) | 0.474 | |
IL-10, pg/ml | 4.61(3.90;8.89) | 3.90(3.90;4.40) | 0.079 | |
TGF-β1, pg/ml | 53.40(43.00;194.80) | 48.80(41.20;54.13) | 0.094 | |
IL-1RA, pg/ml | 1589.90(669.20;3178.55) | 1077.40(512.40;1870.50) | 0.254 | |
IL-1β/IL-10 | 0.41(0.28;0.56) | 0.49(0.36;0.57) | 0.293 | |
TNF-α/IL-10 | 2.33(1.15;2.63) | 2.51(2.20;2.71) | 0.193 | |
IL-8/IL-10 | 8.26(3.66;13.75) | 17.79(8.90;54.86) | 0.002 | 0.735 |
IL-17/IL-10 | 3.85(3.48;3.85) | 3.85(2.27;3.85) | 0.451 | |
MCP-1/ IL-10 | 112.85(39.67;334.84) | 273.21(79.44;433.15) | 0.146 | |
IL-1β/TGF-β1 | 0.03(0.00;0.05) | 0.04(0.03;0.06) | 0.042 | 0.611 |
TNF-α/TGF-β1 | 0.15(0.01;0.26) | 0.21(0.18;0.25) | 0.091 | |
IL-8/TGF-β1 | 0.51(0.13;1.03) | 1.56(0.71;7.73) | 0.001 | 0.018 |
IL-17/TGF-β1 | 0.28(0.23;0.41) | 0.31(0.27;0.36) | 0.505 | |
MCP-1/TGF-β1 | 6.09(0.54;39.10) | 21.57(5.49;58.27) | 0.044 | 0.486 |
IL-1β/IL-1RA | 0.00(0.00;0.00) | 0.00(0.00;0.01) | 0.451 | |
TNF-α/IL-1RA | 0.01(0.00;0.02) | 0.01(0.00;0.02) | 0.354 | |
IL-8/IL-1RA | 0.04(0.01;0.09) | 0.12(0.03;0.53) | 0.033 | 0.517 |
IL-17/IL-1RA | 0.01(0.00;0.03) | 0.01(0.01;0.03) | 0.591 | |
MCP-1/IL-1RA | 0.28(0.18;1.14) | 1.48(0.46;4.43) | 0.012 | 0.329 |
Blood | ||||
TNF-α, pg/ml | 11.10(8.56;18.20) | 13.35(10.03;16.45) | 0.335 | |
IL-8, pg/ml | 23.65(16.53;41.55) | 47.10(26.80;136.60) | 0.002 | 0.397 |
IL-17, pg/ml | 15.00(15.00;15.00) | 15.00(15.00;15.00) | 0.781 | |
MCP-1, pg/ml | 1287.20(374.63;2124.20) | 1014.60(529.10;2683.20) | 0.537 | |
IL-10, pg/ml | 14.05(8.78;26.62) | 33.00(11.60;47.10) | 0.018 | 0.952 |
TGF-β1, pg/ml | 1020.85(245.89;10269.20) | 423.40(205.00;6450.50) | 0.515 | |
IL-1RA, pg/ml | 1678.75(695.58;3536.63) | 565.70(271.33;1594.93) | 0.036 | |
IL-8/IL-10 | 1.74(0.81;2.45) | 1.73(1.25;4.05) | 0.423 | |
IL-8/TGF-β1 | 0.03(0.00;0.12) | 0.12(0.02;0.24) | 0.054 | |
TNF-α/IL-10 | 0.93(0.43;1.23) | 0.45(0.24;0.80) | 0.083 | |
TNF-α/TGF-β1 | 0.01(0.00;0.06) | 0.05(0.00;0.09) | 0.273 |