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Table 2 Gas exchange and lung function variables

From: Surfactant replacement and open lung concept – Comparison of two treatment strategies in an experimental model of neonatal ARDS

a. Gas exchange and lung function variables at different time points

 

Pao2

PaCO2

Cdyn/kg

VT/kg

Res

VEI

ΔP

Healthy (H)

       

   PPVOLC

74.21 ± 16.75

5.67 ± 2.05

1.94 ± 0.89

16.0 ± 4.8

37.62 ± 8.09

0.29 ± 0.17

10.20 ± 0.45

   mon SP-B

64.11 ± 34.10

3.75 ± 0.75

2.56 ± 0.50

20.4 ± 2.7

40.50 ± 8.63

0.35 ± 0.08

10.00 ± 0.00

   nat SF

78.44 ± 15.09

5.29 ± 1.95

2.12 ± 0.87

19.2 ± 7.0

37.88 ± 7.43

0.29 ± 0.14

10.25 ± 0.50

Lavaged (T = 0)

       

   PPVOLC

6.70 ± 3.04 **

6.95 ± 2.84

0.56 ± 0.23 *

11.3 ± 2.6

52.43 ± 13.53 *

0.10 ± 0.06 *

20.00 ± 0.00

   mon SP-B

9.24 ± 0.79*

3.86 ± 1.64

1.21 ± 0.42 *

21.0 ± 5.0

63.28 ± 15.30 *

0.11 ± 0.02 **

20.00 ± 0.00

   nat SF

8.16 ± 1.26 **

5.57 ± 1.35

0.88 ± 0.35 *

16.3 ± 5.4

50.25 ± 11.95 *

0.10 ± 0.04 *

20.00 ± 0.00

1 h

       

   PPVOLC

9.68 ± 2.26

6.91 ± 2.07

0.57 ± 0.20

11.3 ± 4.5

47.50 ± 12.90

0.09 ± 0.04

20.00 ± 0.00

   mon SP-B

38.60 ± 24.14

3.83 ± 2.84

1.52 ± 0.66

22.9 ± 8.4

58.55 ± 14.04

0.16 ± 0.09

19.50 ± 1.00

   nat SF

56.86 ± 14.62

3.75 ± 1.13

1.50 ± 0.43

23.1 ± 6.2

53.98 ± 14.52

0.14 ± 0.05

20.00 ± 0.00

2 h

       

   PPVOLC

71.45 ± 20.29

4.49 ± 1.97

1.03 ± 0.38

10.2 ± 2.2

34.34 ± 8.13

0.33 ± 0.20

12.60 ± 1.82

   mon SP-B

64.87 ± 29.48

3.51 ± 0.91

1.53 ± 0.10

16.1 ± 7.0

47.80 ± 20.69

0.33 ± 0.27

13.75 ± 3.86

   nat SF

75.18 ± 19.67

4.12 ± 0.41

1.39 ± 0.31

18.6 ± 4.0

45.20 ± 7.52

0.16 ± 0.02

17.75 ± 1.71

3 h

       

   PPVOLC

74.08 ± 12.99

5.19 ± 2.35

1.13 ± 0.75

9.9 ± 3.0

34.76 ± 10.65

0.30 ± 0.19

12.40 ± 2.07

   mon SP-B

59.05 ± 33.81

4.77 ± 1.11

1.23 ± 0.14

14.7 ± 4.1

50.63 ± 14.95

0.19 ± 0.12

14.00 ± 3.74

   nat SF

72.32 ± 17.01

4.81 ± 0.55

1.15 ± 0.30

17.1 ± 5.0

43.85 ± 9.29

0.15 ± 0.04

17.00 ± 0.82

4 h

       

   PPVOLC

70.09 ± 12.32

5.54 ± 1.67

1.11 ± 0.73

9.7 ± 2.4

35.46 ± 7.11

0.26 ± 0.15

12.60 ± 3.21

   mon SP-B

60.05 ± 33.26

4.73 ± 1.28

1.21 ± 0.15

14.8 ± 3.4

53.70 ± 19.89

0.18 ± 0.11

14.50 ± 3.87

   nat SF

56.53 ± 11.97

5.37 ± 0.53

1.05 ± 0.27

15.5 ± 2.8

44.18 ± 11.66

0.14 ± 0.04

16.50 ± 0.58

5 h

       

   PPVOLC

71.61 ± 9.23

5.25 ± 1.01

0.97 ± 0.51

9.6 ± 3.2

35.78 ± 8.46

0.25 ± 0.14

12.80 ± 3.27

   mon SP-B

60.38 ± 33.21

5.49 ± 1.17

1.04 ± 0.22

13.1 ± 3.7

51.93 ± 14.55

0.16 ± 0.08

14.0 ± 4.69

   nat SF

48.94 ± 20.65

5.20 ± 0.52

1.01 ± 0.25

15.0 ± 2.2

50.55 ± 13.11

0.12 ± 0.04

17.00 ± 0.82

b. Overall differences in gas exchange and lung function variables (T5 - T0)

 

Pa o2

Pa CO2

C dyn /kg

VT/kg

Res

VEI

ΔP

T5 - T0

       

   PPVOLC

64.90 ± 9.22

-1.71 ± 2.57

0.42 ± 0.40

-2.75 ± 0.96

-17.2 ± 5.43

0.19 ± 0.078 */§

-7.2 ± 3.27

   mon SP-B

51.14 ± 33.47

1.63 ± 1.27

-0.18 ± 0.42

-8.0 ± 4.24 *

-11.35 ± 13.10

0.043 ± 0.07

-6.0 ± 4.69

   nat SF

40.78 ± 20.49

-0.38 ± 1.71

0.13 ± 0.27

-1.25 ± 3.59

0.3 ± 5.91

0.02 ± 0.06

-3 ± 0.82

  1. mean ± SD; open lung concept positive pressure ventilation (PPVOLC; n = 5); surfactant treatment under conventional positive pressure ventilation: natural bovine surfactant (Alveofact®; nat SF; n = 4), monomeric surfactant protein B based surfactant (mon SP-B; n = 4). * p < 0.05; ** p < 0.01 vs initial values (healthy; H). Further levels of significance (two-way ANOVA) are given in detail in the text.
  2. * p < 0.05 vs nat SF
  3. § p < 0.05 vs mon SP-B
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BMC Pulmonary Medicine

ISSN: 1471-2466

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