Lung diffusing capacity for nitric oxide and carbon monoxide in relation to morphological changes as assessed by computed tomography in patients with cystic fibrosis

Table 2 Spearman rank coefficients between CT scores according to Brody et al. [13] and z-scores of lung function measures as obtained in bivariate analyses.

	Bronchiectasis	Mucous plugging	Peribronchial thickening	Parenchyma	Overall CT Score
DL_NO/Dm	-0.78***	-0.73***	-0.79***	-0.60**	-0.83***
DL_CO	-0.75***	-0.73***	-0.76***	-0.59**	-0.79***
KNO	-0.53*	-0.56**	-0.62**	-0.40	-0.63**
KCO	0.10	0.02	0.03	0.23	0.01
Vc, mL^§	-0.64**	-0.58**	-0.59**	-0.50*	-0.63**
IVC	-0.50*	-0.51*	-0.54*	-0.50*	-0.55*
FEV₁	-0.56**	-0.53*	-0.59**	-0.43	-0.59**
SR_AW, kPa × s^$	0.69***	0.61**	0.71***	0.61**	0.72***
RV	0.47*	0.43*	0.50*	0.35	0.51*
RV/TLC, %^§	0.64**	0.58**	0.65**	0.51*	0.66**

^§No z-scores used due to lack of sufficient and standardised data
^$ No z-scores used, as reference equations are not commonly used for interpretation
P values refer to individual pairwise correlations. Correlations remaining significant, when using Bonferroni adjusted alpha levels are indicated in bold. *p < 0.05;**p < 0.01;***p < 0.001, for abbreviations see Table 1

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