Table 3 Peak FEV1 [L] treatment comparisons by subgroups − FAS
Subgroup | Subgroup level | Number of patients ALB-HFA 108/CVT-MDI 18/103 | Subgroup by treatment interaction | Difference (CVT-MDI 18/103 – ALB-HFA 108) | ||
|---|---|---|---|---|---|---|
p value* | Mean (SE) | 95 % CI | P value | |||
Onset of asthma | 0.7890 | |||||
Early | 98/98 | 0.076 (0.024) | (0.028, 0.124) | 0.0023 | ||
Late | 117/114 | 0.078 (0.021) | (0.037, 0.118) | 0.0003 | ||
Type of asthma (based on patient history) | 0.3838 | |||||
Allergic | 182/181 | 0.082 (0.017) | (0.049, 0.116) | <.0001 | ||
Non−allergic | 33/31 | 0.067 (0.035) | (−0.005, 0.138) | 0.0679 | ||
% Predicted FEV1 categories | 0.1378 | |||||
≤45 % | 17/19 | 0.004 (0.046) | (−0.094, 0.102) | 0.9317 | ||
>45 % and ≤ 55 % | 33/32 | 0.142 (0.040) | (0.060, 0.225) | 0.0013 | ||
>55 % and ≤ 65 % | 55/54 | 0.081 (0.029) | (0.022, 0.140) | 0.0081 | ||
>65 % and ≤ 75 % | 76/75 | 0.059 (0.020) | (0.018, 0.100) | 0.0052 | ||
> 75 % | 34/32 | 0.090 (0.053) | (−0.016, 0.196) | 0.0949 | ||
Concomitant asthma medication usage | 0.5364 | |||||
ICS, with LABA | 153/149 | 0.082 (0.018) | (0.047, 0.117) | <.0001 | ||
ICS, without LABA | 62/63 | 0.071 (0.031) | (0.009, 0.132) | 0.0251 | ||
Puff usage of medication (at baseline, daily average in week prior to visit 3)a | 0.8736 | |||||
≤4 puffs per 24 h day | 143/141 | 0.074 (0.016) | (0.042, 0.107) | <.0001 | ||
>4 and <8 puffs per 24 h | 71/70 | 0.094 (0.035) | (0.025, 0.164) | 0.0083 | ||
≥8 puffs per 24 h day | 1/1 | |||||
Gender | 0.1187 | |||||
Female | 125/127 | 0.090 (0.019) | (0.052, 0.127) | <.0001 | ||
Male | 90/85 | 0.067 (0.024) | (0.018, 0.115) | 0.0076 | ||
Raceb | 0.0980 | |||||
Amer.Ind./Alaska Nat | 1/1 | |||||
Asian | 2/2 | |||||
Black/African Amer. | 42/40 | 0.188 (0.050) | (0.089, 0.288) | 0.0004 | ||
Hawaiian/Pacif. Isle | 4/5 | |||||
White | 166/164 | 0.063 (0.015) | (0.034, 0.092) | <.0001 | ||
Age category | 0.7860 | |||||
<35 | 44/41 | 0.077 (0.050) | (−0.023, 0.177) | 0.1280 | ||
≥35,< 50 | 68/69 | 0.083 (0.031) | (0.022, 0.144) | 0.0079 | ||
≥50,< 60 | 62/60 | 0.097 (0.022) | (0.053, 0.142) | <.0001 | ||
≥ 60 | 41/42 | 0.061 (0.030) | (0.001, 0.121) | 0.0459 | ||
Smoking status | 0.9106 | |||||
Ex−smoker | 59/59 | 0.075 (0.037) | (0.002, 0.149) | 0.0436 | ||
Never smoked | 156/153 | 0.076 (0.016) | (0.045, 0.107) | <.0001 | ||
FEV1/FVC [%] pre−BD at Rand | 0.1852 | |||||
<60 | 59/60 | 0.145 (0.036) | (0.074, 0.217) | 0.0001 | ||
≥60,< 65 | 46/45 | 0.100 (0.029) | (0.041, 0.159) | 0.0013 | ||
≥65,< 70 | 43/44 | 0.056 (0.031) | (−0.007, 0.119) | 0.0785 | ||
≥ 70 | 67/63 | 0.013 (0.021) | (−0.028, 0.054) | 0.5431 | ||