The temporal relationship between poor lung function and the risk of diabetes

BMC Pulmonary Medicine

Table 5 Hazard ratios of diabetes mellitus by quartiles of FEV₁%predicted in males: sub-cohort further adjusted for inflammation (5133 men)

follow-up time (years) (n = number of incident DM events)		Q4 (reference)	Q3	Q2	Q1	P value for trend
		≥106.39	95.20–106.39	83.51–95.17	≤83.50
Follow-up time 0–37 years (n = 1025)	Adjusted risk^a	1.00	0.94 (0.78–1.13)	1.24 (1.04–1.48)*	1.36 (1.14–1.63)**	<0.001
Follow-up time 0–37 years (n = 1025)	Further adjusted for inflammation^b	1.00	0.91 (0.75–1.09)	1.20 (1.01–1.44)*	1.29 (1.07–1.54)**	<0.001

^aAdjusted for: age, height, BMI, smoking status, baseline glucose, cholesterol, physical activity, BP medication, social class, family history of diabetes, alcohol abuse ^bFurther adjusted for ESR (log transformed), WCC, Fibrinogen, complement C3, haptoglobin, ceruloplasmin, alpha-1 antitrypsin, and orosomucoid. *p <0.05 **p < 0.01. P value for trend calculated using cox regression models (1 d.f)

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