Healthcare burden of pulmonary hypertension owing to lung disease and/or hypoxia

BMC Pulmonary Medicine

Table 1 Demographic and baseline characteristics of the study population

Characteristic	Group 3 PH (n = 2236)	Controls (n = 2236)	P value
Age at index date, mean (SD), y	67.0 (14.4)	71.0 (11.7)^a	<.001^b
Age group, y
18–30	34 (1.5)	9 (0.4)
31–45	134 (6.0)	49 (2.2)
46–65	841 (37.6)	596 (26.7)
66–85	1035 (46.3)	1383 (61.9)
>86	192 (8.6)	199 (8.9)
Sex
Female	1433 (64.1)	1300 (58.1)	<.001^c
Male	803 (35.9)	936 (41.8)
US census region
North Central	758 (33.9)	933 (41.7)	<.001^c
Northeast	344 (15.4)	260 (11.6)
South	722 (32.3)	669 (29.9)
West	401 (17.9)	372 (16.7)
Unknown	11 (0.5)	2 (0.09)
Health plan type
Comprehensive	879 (39.3)	1368 (61.2)	<.001^c
Health maintenance organization	241(10.8)	218 (9.8)
Point-of-service	136 (6.1)	101 (4.5)
Preferred provider organization	866 (38.7)	505 (22.6)
Others	114 (5.1)	44 (2.0)
CCI^d, mean (SD)	2.80 (2.02)	2.09 (1.70)	<.001^b
Underlying lung disease
COPD	1590 (71.1)	1590 (71.1)
Interstitial lung disease	438 (19.6)	438 (19.6)
Sleep disorder breathing	340 (15.2)	340 (15.2)
Developmental lung disease	503 (22.5)	502 (22.5)
Alveolar hyperventilation disorder	6 (0.2)	7 (0.3)

Values are expressed as No. (%) unless otherwise indicated. Some patients had multiple underlying lung diseases and therefore percent total is >100%. P < .05 was considered significant
CCI Charlson comorbidity index, COPD chronic obstructive pulmonary disease, PH pulmonary hypertension, SD standard deviation
^aControls were assigned the index date of the matched Group 3 PH patient
^bStudent’s t-test
^c χ ² test
^dDeyo adaptation of the CCI with several procedure codes that reflect the Romano adaptation

ISSN: 1471-2466