Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension

BMC Pulmonary Medicine

Table 4 Bivariable Cox’s proportional hazards regression analyses regarding transplantation-free survival

Variable	Bivaribale Cox’s proportional hazards regression model^a
	HR, CI and p-value of variable with neutrophils in %			HR, CI and p-value of neutrophils in % with variable
	HR	95% CI	p-value	HR	95% CI	p-value
CRP > 5 mg/dl	1.97	0.86–4.54	0.112	1.05	1.01–1.08	0.014
CVRF ≥ 3^b	0.56	0.13–2.43	0.443	1.06	1.02–1.09	0.002
WHO-FC	2.13	1.06–4.23	0.034	1.04	1.01–1.08	0.021
GFR > 60 ml/min/1.73 m²	1.8	0.75–4.31	0.188	1.04	1.01–1.08	0.019
SvO₂, %	0.97	0.95–0.99	0.013	1.05	1.01–1.1	0.015
Idiopathic vs. non-idiopathic	1.47	0.62–3.48	0.382	1.06	1.02–1.09	0.002
	HR, CI and p-value of variable with neutrophils/lymphocytes ratio			HR, CI and p-value of neutrophils/lymphocytes ratio with variable
	HR	95% CI	p-value	HR	95% CI	p-value
CRP > 5 mg/dl	2.56	1.13–5.82	0.025	1.05	1.02–1.09	0.004
CVRF ≥ 3^b	0.31	0.04–2.47	0.265	1.06	1.02–1.11	0.007
WHO-FC	2.23	1.17–4.67	0.016	1.03	1–1.07	0.064
GFR > 60 ml/min/1.73 m²	2.17	0.95–4.99	0.067	1.04	1–1.07	0.033
SvO₂, %	0.97	0.95–0.99	0.013	1.04	1.01–1.08	0.015
Idiopathic vs. non-idiopathic	1.19	0.49–2.9	0.706	1.04	1.01–1.08	0.012

^aSeparate bivariate models for each given parameter with either relative count of neutrophils or the neutrophil/lymphocyte ratio
^bCVRF including arterial hypertension, diabetes mellitus, coronary heart disease, atrial fibrillation and body mass index
CI confidence interval, CRP C-reactive protein, CVRF cardiovascular risk factors, GFR glomerular filtration rate, HR hazard ratio, SvO2 oxygen saturation of mixed venous blood, WHO-FC World Health Organization functional class

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