Fig. 1

Exacerbation rates during the follow-up period by a GINA category; b exacerbation history, and c severe and severe uncontrolled eosinophilic asthma. Severe asthma defined as patients at GINA Step 4 or 5 with ≥2 exacerbations in the previous 12 months; Severe eosinophilic asthma defined as patients with severe uncontrolled asthma criteria and blood eosinophil counts ≥300 cells/μl at baseline. GINA, Global Initiative for Asthma