Table 1 Patient demographics and baseline characteristics (ITT population)

Age, mean (SD), years^a

37.2 (14.4)

39.1 (14.4)

41.9 (15.4)

41.4 (13.5)

45.8 (14.3)

43.1 (12.4)

35.8 (16.0)

35.6 (15.8)

40.0 (16.6)

40.1 (17.2)

43.7 (16.2)

42.6 (16.3)

Female, n (%)^a

67 (56)

75 (61)

62 (58)

61 (59)

53 (52)

63 (65)

245 (57)

241 (56)

278 (58)

288 (61)

276 (58)

279 (58)

Height, mean (SD), cm^a

161.9 (9.5)

158.6 (8.8)

161.3 (8.9)

162.7 (8.8)

161.6 (9.5)

161.3 (7.9)

167.8 (9.8)

167.7 (10.1)

166.5 (10.2)

166.5 (10.2)

167.1 (10.1)

166.6 (10.3)

Weight, mean (SD), kg^a

60.8 (12.9)

58.6 (11.7)

61.5 (11.3)

61.8 (11.1)

63.2 (14.0)

61.7 (10.6)

72.4 (17.6)

71.8 (17.9)

72.6 (16.7)

72.7 (17.9)

74.5 (16.5)

73.4 (16.4)

BMI, mean (SD)^a

23.15

(4.57)

23.25

(3.94)

23.59

(3.69)

23.28

(3.41)

24.07

(4.33)

23.68

(3.37)

25.63 (5.72)

25.41 (5.73)

26.16 (5.52)

26.10 (5.56)

26.59

(5.09)

26.53 (5.46)

Mean FEV₁ at visit 2 (SD), L^b

2.08 (0.69)

n = 118

1.92 (0.68)

n = 121

1.91 (0.64)

n = 107

1.97 (0.58)

n = 104

1.93 (0.75)

n = 102

2.04 (0.68)

n = 95

2.61 (0.88)

n = 421

2.69 (0.82)

n = 423

2.53 (0.82)

n = 476

2.46 (0.82)

n = 473

2.36 (0.81)

n = 466

2.38 (0.79)

n = 472

Mean % predicted^c FEV₁ at visit 2 (SD), %^b

68.6 (16.6)

n = 118

67.6 (17.0)

n = 121

66.7 (16.8)

n = 107

67.0 (15.6)

n = 104

67.3 (17.1)

n = 102

71.1 (16.8)

n = 95

78.8 (18.6)

n = 421

81.8 (18.0)

n = 423

80.4 (17.6)

n = 476

79.3 (18.2)

n = 473

76.2 (18.6)

n = 466

77.1 (17.6)

n = 472

Median pre-randomisation reversibility, (min., max.), %

21.4 (10.5, 95.2)

n = 91

20.0 (9.0, 112.5)

n = 98

25.0 (2.7, 124.7)

n = 87

24.0 (11.1, 78.9)

n = 80

25.3 (4.2, 92.0)

n = 63

20.2 (8.3, 68.6)

n = 67

23.8 (1.0,

95.7)

n = 318

22.0 (2.5, 97.0)

n = 324

21.4 (−0.6, 123.6)

n = 346

21.6 (3.7, 111.5)

n = 346

22.2 (−0.4, 115.3)

n = 356

21.9 (3.1, 224.0)

n = 366

Mean am PEF (SD), L/min

310.5 (76.3)

n = 120

299.0 (72.7)

n = 122

312.3 (92.3)

n = 107

311.0 (70.9)

n = 104

320.1 (84.2)

n = 102

327.9 (90.5)

n = 97

353.8 (92.9)

n = 427

358.4 (93.8)

n = 427

356.9 (98.0)

n = 478

350.7 (96.5)

n = 474

350.4 (100.8)

n = 473

352.5 (97.0)

n = 482

Mean % predicted^b am PEF (SD), %

71.1 (14.1)

n = 120

71.9 (14.4)

n = 122

74.1 (18.4)

n = 107

72.7 (15.9)

n = 104

74.8 (14.4)

n = 102

77.5 (17.2)

n = 97

76.9 (14.5)

n = 427

77.9 (14.1)

n = 427

79.4 (15.3)

n = 478

79.3 (16.2)

n = 474

78.4 (16.2)

n = 473

79.2 (16.0)

n = 482

Mean daily rescue usage, (SD)

1.9 (1.6)

n = 120

1.7 (1.3)

n = 122

1.7 (1.3)

n = 107

1.5 (1.1)

n = 103

1.5 (1.5)

n = 102

1.6 (1.4)

n = 97

2.0 (1.7)

n = 426

1.8 (1.5)

n = 428

1.8 (1.5)

n = 478

1.8 (1.5)

n = 473

2.0 (1.4)

n = 473

2.0 (1.4)

n = 482

Median night-time awakenings, (min., max.)

0.5 (0, 3)

n = 120

0.5 (0, 3)

n = 122

0.2 (0, 3)

n = 107

0.2 (0, 2)

n = 104

0.2 (0, 2)

n = 102

0.3 (0, 4)

n = 95

0.4 (0, 4)

n = 425

0.3 (0, 4)

n = 427

0.2 (0, 3)

n = 476

0.2 (0, 3)

n = 471

0.3 (0, 4)

n = 471

0.2 (0, 3)

n = 479

Mean asthma symptom score, (SD)

1.9 (0.8)

n = 120

1.7 (0.8)

n = 121

1.7 (0.9)

n = 107

1.6 (0.8)

n = 104

1.6 (0.9)

n = 102

1.8 (1.0)

n = 97

1.8 (0.8)

n = 427

1.7 (0.9)

n = 428

1.8 (0.9)

n = 478

1.8 (0.9)

n = 473

2.0 (0.9)

n = 472

1.9 (0.9)

n = 482

Patients with atopy, n (%)^a

54 (45)

46 (38)

54 (50)

59 (57)

62 (61)

46 (47)

259 (61)

253 (59)

298 (62)

278 (59)

300 (63)

290 (60)

Patients with unknown atopy, n (%)^a

8 (7)

10 (8)

13 (12)

9 (9)

18 (18)

10 (10)

46 (11)

34 (8)

31 (6)

25 (5)

32 (7)

30 (6)