NRAMP1 and VDR gene polymorphisms in susceptibility to pulmonary tuberculosis among Andhra Pradesh population in India: a case–control study

Table 2 Association between the SNPs genotypes of NRAMP1, VDR and the risk of Pulmonary Tuberculosis

Gene	polymorphism	type	patients		controls		Χ²	Odds ratio	95% C.I	P
			N	%	N	%
NRAMP1-3′UTR	TGTG++	Wild homozygous	72	79.1	83	94.3	10.289	1		0.005*
	TGTG+/del	Heterozgous	13	14.3	5	5.7		2.997	1.019–8.813
	TGTGdel/TGTGdel	Mutant homozygous	6	6.6	0	0.0		14.972	0.829–270.38
	Alleles
	TGTG		157	86.3	171	97.2	13.835	1		<0.001*
	TGTGdel		25	13.7	5	2.8	13.835	5.445	2.035–14.573	<0.001*
NRAMP1-274C/T	C/C	Wild homozygous	68	73.9	69	83.1	5.559	1		0.062
	C/T	Heterozygous	24	26.1	12	14.5		2.029	0.940–4.381
	T/T	Mutant homozygous	0	0.0	2	2.4		0.202	0.009–4.304
	Alleles
	C		160	87.0	150	90.4	1.000	1		0.317
	T		24	13.0	16	9.6	1.000	1.4063	0.719–2.750	0.317
VDR-Fok1	FF	Wild homozygous	5	5.6	12	14.5	4.543	1		0.103
	Ff	heterozygous	76	85.4	61	73.5		2.9902	0.999–8.950
	ff	Mutant homozygous	8	9.0	10	12.0		1.920	0.474–7.766
	Alleles
	F		86	48.3	85	51.2	0.287			0.592
	f		92	51.7	81	48.8	0.287	1.122	0.735–1.713	0.592
VDR-Taq1	TT	Wild homozygous	27	29.3	5	5.9	17.719	1		<0.001*
	Tt	heterozygous	56	60.9	74	87.1		0.140	0.050–0.386
	tt	Mutant homozygous	8	8.7	6	7.1		0.246	0.059–1.026
	alleles
	T		110	60.4	84	49.4	4.321	1		0.030*
	t		72	39.6	86	50.6	4.321	0.639	0.418–0.975	0.030*
*P value significant @5% level (P < 0.05)

Note: Genotype and allele frequencies were compared between the patients and controls by χ2 test. N = sample size, 95% C.I = 95% confidence interval. * = p value <0.05 indicates statistical significance

ISSN: 1471-2466