All | Azithromycin | Fluoroquinolone | p value | |
---|---|---|---|---|
n = 85 | n = 38 | n = 47 | ||
Age | 76 (70–80) | 75.5 (64–79) | 76 (71–81.5) | 0.65 |
Male sex | 66 (78) | 32 (84) | 34 (72) | 0.3 |
IPF diagnosis | ||||
Honeycombing and/or surgical lung biopsy | 78 (92) | 35 (92) | 43 (91) | 1 |
Possible UIP with traction bronchiectasis | 7 (8) | 3 (8) | 4 (9) | |
Surgical lung biopsy | 16 (19) | 5 (13) | 11 (23) | 0.274 |
HRCT pattern of AE | ||||
Diffuse | 77 (91) | 32 (84) | 45 (96) | 0.132 |
Multifocal | 8 (9) | 6 (16) | 2 (4) | |
Corticosteroid use before admission | 39 (46) | 17 (45) | 22 (47) | 1 |
Immunosuppressant before admission | 19 (22) | 7 (18) | 12 (26) | 0.6 |
Antifibrotic drug before admission | 15 (18) | 10 (26) | 5 (11) | 0.086 |
Anticoagulant drug before admission | 6 (7) | 2 (5) | 4 (9) | 0.69 |
APACHE II score | 16 (13–18) | 15.5 (13–18) | 16 (13–18) | 0.546 |
PaO2/FiO2 | 165 (99–243) | 159 (109–241) | 167 (97–236) | 0.933 |
Lactate dehydrogenase (IU/L) | 340 (291–408) | 323 (281–385) | 355 (308–442) | 0.079 |
C-reactive protein (mg/dl) | 6.4 (3.0–11.1) | 6.0 (2.9–9.0) | 7.7 (3.2–12.6) | 0.482 |
KL-6 (U/ml) | 1280 (860–2110) | 1085 (760–1703) | 1380 (887–2430) | 0.088 |
Surfactant protein D (ng/ml), n = 75 | 336 (222–515) | 336 (248.5–567.5) | 333 (211–494) | 0.527 |