Table 1 Clinical characteristics of subjects with borderline or less severe PH (mPAP <35 mmHg)
Untreated borderline or less severe PH | Drug-treated borderline or less severe PH | P * | |
|---|---|---|---|
No. (male/female) | 12(8/4) | 12(9/3) | 0.66 |
Age (y.o.) | 70.50 ± 7.97 | 66.92 ± 6.45 | 0.11 |
Height (cm) | 160.04 ± 10.11 | 160.87 ± 10.07 | 0.84 |
Weight (kg) | 62.067 ± 12.17 | 54.95 ± 12.72 | 0.25 |
No. of patients with LTOT | 8 | 7 | 0.67 |
ADL including exercise tolerance test | |||
WHO functional class | 2.67 ± 0.78 | 2.83 ± 0.83 | 0.78 |
mMRC score | 2.42 ± 1.084 | 2.33 ± 1.44 | 0.98 |
SGRQ score | |||
Symptoms | 56.10 ± 22.87 | 45.78 ± 28.96 | 0.52 |
Activity | 61.60 ± 22.35 | 55.18 ± 33.21 | 0.98 |
Impact | 37.53 ± 23.11 | 34.38 ± 22.18 | 0.91 |
Total | 49.42 ± 21.27 | 43.93 ± 26.41 | 0.77 |
SF36 | |||
Physical functioning (PF) | 45.83 ± 21.41 | 60.42 ± 26.41 | 0.11 |
Role physical (RP) | 38.58 ± 21.96 | 51.058 ± 39.16 | 0.56 |
Bodily pain (BP) | 72.17 ± 26.30 | 80.00 ± 25.23 | 0.45 |
General health (GH) | 40.67 ± 18.34 | 46.75 ± 20.067 | 0.49 |
Vitality (VT) | 49.34 ± 20.55 | 58.36 ± 29.23 | 0.40 |
Social functioning (SF) | 56.25 ± 26.38 | 68.75 ± 33.50 | 0.35 |
Role emotional (RE) | 62.51 ± 30.048 | 67.36 ± 37.69 | 0.52 |
Mental health (MH) | 63.75 ± 19.67 | 65. 00 ± 27.88 | 0.62 |
Right heart cardiography | |||
mPAP (mmHg) | 20.83 ± 5.75 | 21.17 ± 7.73 | 0.93 |
mPAPOE (mmHg) | 42.67 ± 12.78 | 42.58 ± 8.87 | 0.45 |
mPAWP (mmHg) | 6.83 ± 3.79 | 6.28 ± 3.57 | 0.76 |
mRVP (mmHg) | 14.42 ± 3.58 | 14.083 ± 6.57 | 0.31 |
mRAP (mmHg) | 2.50 ± 1.68 | 3.00 ± 2.13 | 0.45 |
CO (L/min) | 4.80 ± 1.12 | 5.10 ± 1.27 | 0.82 |
CI (L/min/m2) | 2.90 ± 0.56 | 3.21 ± 0.63 | 0.38 |
PVR (wood) | 3.12 ± 1.65 | 3.022 ± 2.0031 | 0.95 |
PVRI | 5.073 ± 2.67 | 4.58 ± 2.61 | 1.00 |
Mixed venous | |||
PHv | 7.39 ± 0.029 | 7.40 ± 0.026 | 0.45 |
PvCO2 (mmHg) | 49.34 ± 6.036 | 48.15 ± 4.22 | 0.82 |
PvO2 (mmHg) | 36.69 ± 3.89 | 37.55 ± 3.93 | 0.60 |
SVO2 (%) | 68.77 ± 5.47 | 70.53 ± 5.71 | 0.66 |
PFT | |||
%VC (%) | 68.34 ± 16.92 | 69.55 ± 22.62 | 0.98 |
FVC (L) | 2.0033 ± 0.57 | 2.087 ± 0.80 | 0.86 |
%DLCO (%) | 30.72 ± 16.0019 | 27.37 ± 23.76 | 0.25 |
TTE | |||
ET (msec) | 299.71 ± 55.95 | 263.83 ± 36.16 | 0.18 |
PAAcT (msec) | 98.67 ± 32.65 | 94.75 ± 11.65 | 0.58 |
AcT/ET | 0.33 ± 0.087 | 0.37 ± 0.060 | 0.23 |
PEP (msec) | 92.71 ± 12.65 | 87.42 ± 18.62 | 0.12 |
ICT (msec) | 17.083 ± 19.96 | 21.75 ± 21.73 | 0.70 |
IRT (msec) | 55.71 ± 45.0023 | 52.42 ± 36.49 | 0.95 |
ICT + IRT (msec) | 87.79 ± 64.54 | 72.82 ± 46.34 | 0.69 |
TEI index | 0.32 ± 0.27 | 0.30 ± 0.25 | 0.98 |
TAPSE(cm) | 2.32 ± 0.47 | 2.27 ± 0.55 | 0.75 |
Diastolic RA area (cm2) | 8.20 ± 3.21 | 10.64 ± 4.91 | 0.29 |
Diastolic RA major axis (cm) | 4.35 ± 2.0037 | 4.20 ± 2.018 | 0.66 |
Systolic RA area (cm2) | 4.74 ± 2.10 | 5.46 ± 2.60 | 0.60 |
Systolic RA major axis (cm) | 2.95 ± 0.99 | 2.65 ± 0.55 | 0.25 |
Diastolic RV area (cm2) | 16.090 ± 6.57 | 15.39 ± 7.96 | 0.33 |
Diastolic RV major axis (cm) | 6.38 ± 1.28 | 6.22 ± 1.098 | 0.49 |
Systolic RV area (cm2) | 9.27 ± 3.47 | 9.38 ± 4.38 | 0.64 |
Systolic RV major axis (cm) | 4.98 ± 1.42 | 4.95 ± 0.89 | 0.60 |
RVEF (%) | 58.91 ± 12.45 | 51.98 ± 13.29 | 0.13 |
Aortic Blood data at rest | |||
pH | 7.41 ± 0.027 | 7.42 ± 0.022 | 0.25 |
PO2 (mmHg) | 76.84 ± 10.091 | 82.46 ± 7.93 | 0.11 |
Aortic oxygen saturation (%) | 95.02 ± 1.55 | 95.85 ± 1.20 | 0.12 |
BNP (pg/ml) | 29.42 ± 20.26 | 20.76 ± 13.10 | 0.34 |
NT-proBNP (pg/ml) | 93.33 ± 60.15 | 69.67 ± 48.21 | 0.45 |
LA (mg/dl) | 11.82 ± 4.082 | 10.00 ± 3.53 | 0.33 |
TMET | |||
METS | 3.55 ± 1.89 | 3.96 ± 2.54 | 0.81 |
Post-TMET Aortic Blood data | |||
Post-TMET pH | 7.34 ± 0.061 | 7.36 ± 0.069 | 0.45 |
Post-TMET PCO2 (mmHg) | 46.94 ± 12.22 | 43.017 ± 6.75 | 0.66 |
Post-TMET PO2 (mmHg) | 54.075 ± 15.93 | 67.23 ± 14.71 | 0.18 |
Post-TMET oxygen-Sat (%) | 80.35 ± 18.077 | 90.85 ± 4.42 | 0.14 |
Post-TMET BNP (pg/ml) | 40.20 ± 34.88 | 35.62 ± 46.66 | 0.27 |
Post-TMETNT-proBNP (pg/ml) | 102.83 ± 67.48 | 108.67 ± 124.95 | 0.64 |
LA post TMET – LA at rest (mg/dl) | 24.68 ± 20.012 | 22.82 ± 18.88 | 0.98 |
6MWD | 246.18 ± 104.27 | 296.63 ± 128.0090 | 0.31 |
Post-6 MW Aortic Blood data | |||
Post-6MWT pH | 7.39 ± 0.021 | 7.40 ± 0.039 | 0.15 |
Post-6 MW-PCO2 (mmHg) | 41.042 ± 8.32 | 42.64 ± 5.42 | 0.53 |
Post-6 MW-PO2 (mmHg) | 77.20 ± 30.98 | 72.067 ± 15.79 | 0.91 |
Post-TMET Oxygen-Sat (%) | 92.58 ± 4.13 | 90.00 ± 8.35 | 0.69 |
Post-6 MW-BNP (pg/ml) | 34.52 ± 25.66 | 25.080 ± 23.95 | 0.33 |
Post-6 MW-NT-proBNP (pg/ml) | 98.50 ± 75.13 | 80.67 ± 72.41 | 0.47 |
LA post-6 MW – LA at rest (mg/dl) | 8.60 ± 8.31 | 5.42 ± 8.34 | 0.14 |