Table 2 Comparison of characteristics of patients according to comorbidities
|  | Comorbidities (0) (n = 23) | Comorbidities (1) (n = 69) | Comorbidities(2) (n = 56) | Comorbidities(≥3) (n = 35) | P Value |
|---|---|---|---|---|---|
Age (years) | 53.0 (40.0–59.0) | 48.0 (33.5–61.5) | 51.5 (37.5–59.5) | 50.0 (37.0–63.0) | 0.858 |
Sex, female | 13 (56.5%) | 31 (44.9%) | 16 (28.6%) | 18 (51.4%) | 0.765 |
Age of diagnosis (years) | 45.0 (20.0–54.0) | 34.0 (15.0–50.0) | 35.5 (20.0–48.0) | 33.0 (20.0–46.0) | 0.350 |
Duration of asthma | 8.0 (3.0–17.0) | 8.0 (4.0-19.5) | 7.5 (4.0–20.0) | 7.0 (5.0–25.0) | 0.802 |
Pre-bronchodilatorFEV1% pred (n = 175) | 73.7 ± 25.1 | 68.8 ± 23.7 | 69.8 ± 23.9 | 66.2 ± 25.7 | 0.723 |
Pre-bronchodilator FEV1/FVC(%) (n = 177) | 68.4 ± 14.3 | 65.8 ± 14.7 | 64.2 ± 14.4 | 63.3 ± 15.3 | 0.575 |
Post-bronchodilator FEV1% pred (n = 152) | 76.0 ± 25.3 | 77.7 ± 21.5 | 77.2 ± 23.2 | 70.7 ± 24.7 | 0.593 |
Post-bronchodilator FEV1/FVC(%) (n = 157) | 71.6 (61.4–80.8) | 70.7 (62.5–81.4) | 70.6 (60.0-80.2) | 64.8 (60.7–83.1) | 0.764 |
FENO, ppb (n = 128) | 58.0 (19.0-99.5) | 45.5 (26.5–63.8) | 43.0 (23.0–95.0) | 31.0 (17.3–48.0) | 0.201 |
Blood neutrophil (%) (n = 125) | 61.7 (52.3–68.9) | 57.1 (50.8–68.3) | 57.3 (50.9–64.3) | 59.9 (52.4–64.1) | 0.764 |
Blood neutrophil (/ul) (n = 123) | 4700.0(3675.0-5825.0) | 4000.0 (3325.0-5425.0) | 4000.0 (3190.0-4975.0) | 4400.0 (3220.0-6800.0) | 0.339 |
Blood eosinophil (%) (n = 138) | 3.9 (1.0-8.5) | 3.5 (2.0–8.0) | 4.0 (1.8–8.2) | 2.9 (1.1–5.7) | 0.669 |
Blood eosinophil (/ul) (n = 134) | 240.0 (80.0-500.0) | 235.0(150.0-600.0) | 245.0 (110.0-550.0) | 150.0(70.0-355.0) | 0.445 |
Total IgE, IU/ml (n = 148) | 219.0 (124.3-658.3) | 272.0 (92.4–724.0) | 272.0 (109.0-636.0) | 191.0 (120.0-403.0) | 0.825 |
ACT score (n = 164) | 21.0 (18.5–23.0) | 20.5 (19.0–23.0) | 20.0 (19.0–22.0) | 18.0(16.0–21.0) | 0.004 |
AQLQ score (n = 122) | 5.9 (5.5–6.2) | 4.7 (3.2–5.9) | 4.6 (3.7–5.6) | 4.0 (2.9–5.2) | 0.007 |
GINA step 5 | 13 (56.5%) | 29 (42.0%) | 18 (32.1%) | 21 (60.0%) | 0.039 |
Number of exacerbations | 0 (0–2) | 0 (0–2) | 1 (0–2) | 2 (0–3) | 0.102 |
Corticosteroids treatment for at least 3 days | 7 (30.4%) | 20 (29.0%) | 25 (44.6%) | 21 (60.0%) | 0.013 |
Emergency department visit or hospitalization | 3 (13.0%) | 15 (21.7%) | 11 (19.6%) | 5 (14.3%) | 0.791 |