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Table 4 Comparison of characteristics between patients with BMI ≥ 24 and BMI < 24

From: Clinical characteristics of obese, fixed airway obstruction, exacerbation-prone phenotype and comorbidities among severe asthma patients: a single-center study

 

BMI ≥ 24 (n = 125)

BMI < 24 (n = 103)

P Value

Age (years)

53.0 (40.5–62.0)

50.0 (36.0–63.0)

0.194

Sex, female

49 (39.2%)

59 (57.3%)

0.007

Age of diagnosis (years)

41.0 (20.0-50.5)

37.0 (23.0–51.0)

0.838

Duration of asthma

8.0 (4.0–20.0)

6.0 (3.0–15.0)

0.036

Pre-bronchodilator FEV1% pred (n = 219)

66.0 ± 22.5

72.3 ± 25.4

0.055

Pre-bronchodilator FEV1/FVC (%) (n = 221)

64.1 ± 12.9

65.8 ± 16.3

0.408

Post-bronchodilator FEV1% pred (n = 184)

72.1 ± 22.3

80.7 ± 22.9

0.011

Post-bronchodilator FEV1/FVC (%) (n = 189)

68.2 (61.5–78.3)

71.8 (61.8–83.4)

0.105

FENO, ppb (n = 161)

37.5 (23.8–65.8)

48.0 (26.0–95.0)

0.169

Blood neutrophil (%) (n = 159)

57.3 (50.8–62.9)

57.1(50.7–66.1)

0.799

Blood neutrophil (/ul) (n = 157)

4100.0(3300.0-5500.0)

3900.0 (3300.0-5200.0)

0.630

Blood eosinophil (%) (n = 172)

3.9 (2.1–8.2)

3.4 (1.5–7.6)

0.420

Blood eosinophil (/ul) (n = 168)

235.0 (140.0-572.5)

235.0 (110.0-530.5)

0.514

Total IgE, IU/ml (n = 186)

227.0 (96.6-564.5)

272.0 (86.6-491.5)

0.986

ACT score (n = 198)

20.0 (17.0–21.0)

21.0 (19.0–23.0)

0.007

AQLQ score (n = 130)

4.4 (3.5–5.4)

4.7 (3.4–5.8)

0.521

GINA step 5

54 (43.2%)

42 (40.8%)

0.712

Number of exacerbations

0 (0–2)

0 (0–2)

0.568

Corticosteroids treatment for at least 3 days

47 (37.6%)

37 (35.9%)

0.794

Emergency department visit or hospitalization

23 (18.4%)

17 (16.5%)

0.687

Number of comorbidities (n = 183)

  

0.018

0

10 (10.2%)

13 (15.3%)

 

1

30 (30.6%)

39 (45.9%)

 

2

32 (32.7%)

24 (28.2%)

 

≥ 3

26 (26.5%)

9 (10.6%)

 
  1. Values are presented as number (%) and mean ± SD or median with interquartile range
  2. Abbreviations: FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; FENO, fractional exhaled nitric oxide; ACT, asthma control test; AQLQ, asthma quality of life questionnaire