Fig.1

Flow of determining exposure grade using the EAF. In the screening section, antigen screening is performed based on simple exposure histories (item A) and immunological tests (item B). In the grading section, immunological tests (item B), association between exposure and disease behavior (item C), and individual exposure provocation tests (item D) are evaluated to classify the clinical relevance of the antigen into grades G0 to G4. The antigen with the highest grade is considered the most relevant antigen, and this grade is recorded as the exposure grade for the patient. When no antigen is identified in the screening section, the exposure grade is reported as G0