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Table 9 Results of network meta-analysis of FVC (% predicted) absolute change from baseline

From: A comprehensive comparison of the safety and efficacy of drugs in the treatment of idiopathic pulmonary fibrosis: a network meta-analysis based on randomized controlled trials

Ambrisentan

-1.51 (-8.62,5.60) low2,4

Warfarin

      

-2.40 (-8.73,3.93) moderate2

-0.89 (-4.14,2.36) moderate2

Placebo

     

-2.79 (-9.59,4.01) low2,4

-1.28 (-5.37,2.81) low2,4

-0.39 (-2.88,2.10) high

Sildenafil

    

-4.70 (-11.92,2.52) low2,4

-3.19 (-7.95,1.57) low2,4

-2.30 (-5.79,1.19) high

-1.91 (-6.19,2.37) moderate4

Nintedanib

   

-5.05 (-12.12,2.01) low2,4

-3.54 (-8.06,0.97) low2,4

-2.65 (-5.79,0.49) high

-2.26 (-6.30,1.77) moderate4

-0.35 (-5.04,4.34) moderate4

Pirfenidone

  

-6.30 (-13.77,1.17) very low1,2,4

-4.79 (-9.93,0.35) very low1,2,4

-3.90 (-7.88,0.08) moderate1

-3.51 (-8.20,1.18) low1,4

-1.60 (-6.89,3.69) low1,4

-1.25 (-6.31,3.82) low1,4

PRM151

 

-6.70 (-14.50,1.10) low2,4

-5.19 (-10.79,0.41) low2,4

-4.30 (-8.86,0.26) high

-3.91 (-9.10,1.28) moderate4

-2.00 (-7.74,3.74) moderate4

-1.65 (-7.18,3.89) moderate4

-0.40 (-6.45,5.65) low1,4

Pamrevlumab

  1. Data are MD(95%Cl)
  2. 1:Certainty lowered for imprecision
  3. 2:Certainty lowered for individual study risk of bias
  4. 3:Certainty lowered two levels for imprecision
  5. 4:Certainty lowered for indirectness
  6. GRADE Working Group grades of evidence – High quality: Further research is very unlikely to change our confidence in the estimate of effect; Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate; Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate; Very low quality: We are very uncertain about the estimate