Table 1 Study population characteristics by quartiles of Klotho protein
Variable | Total | Klotho Quartiles | H/χ2 | P | |||
|---|---|---|---|---|---|---|---|
Q1(n = 1632) | Q2(n = 1633) | Q3(n = 1631) | Q4(n = 1631) | ||||
FeNO(ppb) | 14.5(9.5,21.5) | 13.5(9,20.5) | 14.5(9,21.5) | 14.5(9.5,22) | 14.5(9.5,21.5) | 7.985 | 0.046 |
Age(years) | 56(48,65) | 58(49,67) | 57(48,65) | 56(48,65) | 54(47,63) | 43.969 | 0.000 |
Male,N(%) | 3311(50.7) | 862(52.8) | 890(54.5) | 822(50.4) | 737(45.2) | 32.260 | 0.000 |
BMI((kg/m2) | 28.61(25.1,32.8) | 28.67(25.2,32.83) | 28.68(25.28,32.55) | 28.6(25.1,32.7) | 28.56(24.81,33.08) | 0.599 | 0.897 |
WBC(*10^3/uL) | 6.8(5.6,8.1) | 6.9(5.7,8.4) | 6.8(5.6,8.2) | 6.7(5.6,8.1) | 6.6(5.4,8) | 25.362 | 0.000 |
NLR | 1.95(1.48,2.58) | 2(1.53,2.72) | 2(1.5,2.54) | 1.93(1.46,2.63) | 1.88(1.42,2.48) | 25.757 | 0.000 |
Eos(*10^3/uL) | 0.2(0.1,0.3) | 0.2(0.1,0.3) | 0.2(0.1,0.3) | 0.2(0.1,0.3) | 0.2(0.1,0.2) | 23.061 | 0.000 |
FEV1(mL) | 2705(2186,3293) | 2665.5(2138.25,3250) | 2732(2231.5,3369) | 2714(2181,3315) | 2697(2190,3261) | 14.109 | 0.003 |
FVC (mL) | 3566(2895,4344) | 3543(2847.25,4321) | 3622(2943.5,4463) | 3551(2918,4344) | 3532(2868,4249) | 14.644 | 0.002 |
PEF (mL/s) | 7455(6072,9088) | 7382.5(5956.75,8984) | 7601(6168,9112.5) | 7465(6049,9265) | 7372(6063,9001) | 8.127 | 0.043 |
FEF25%-75%(mL/s) | 2331(1625,3155) | 2199(1518.25,3026.25) | 2351(1635,3224.5) | 2332(1639,3153) | 2415(1703,3213) | 27.111 | 0.000 |
FEV1/FVC | 77.02(71.76,81.46) | 76.45(70.73,80.82) | 76.86(71.9,81.18) | 76.83(71.89,81.57) | 77.95(72.59,82.02) | 31.991 | 0.000 |
Albumin(g/L) | 42(40,44) | 42(40,44) | 43(41,44) | 42(41,44) | 42(40,44) | 26.179 | 0.000 |
ALT(U/L) | 22(17,29) | 21(17,28) | 22(17,29) | 22(17,29) | 22(17,29) | 10.956 | 0.012 |
AST(U/L) | 24(20,29) | 23(20,28) | 24(21,29) | 24(20,28) | 24(20,29) | 14.524 | 0.002 |
Cholesterol(mmol/L) | 5.15(4.45,5.87) | 5.15(4.37,5.97) | 5.15(4.43,5.9) | 5.17(4.47,5.84) | 5.15(4.45,5.82) | 0.980 | 0.806 |
BUN (mmol/L) | 4.64(3.57,5.71) | 4.64(3.57,6.07) | 4.64(3.57,5.71) | 4.64(3.57,5.71) | 4.28(3.57,5.36) | 42.918 | 0.000 |
Creatinine(mmol/L) | 76.02(64.53,90.17) | 79.56(65.42,93.7) | 76.91(64.53,90.17) | 76.02(64.53,88.4) | 72.49(63.65,87.52) | 59.019 | 0.000 |
LDH(U/L) | 131(116,147) | 129(115,147) | 130(116,145) | 131(116,146) | 133(118,150) | 18.874 | 0.000 |
Phosphorus(mmol/L) | 1.2(1.07,1.32) | 1.2(1.07,1.29) | 1.2(1.1,1.32) | 1.2(1.07,1.32) | 1.2(1.1,1.29) | 0.985 | 0.805 |
Calcium(mmol/L) | 2.35(2.3,2.4) | 2.35(2.3,2.4) | 2.35(2.3,2.4) | 2.35(2.3,2.4) | 2.35(2.3,2.4) | 3.750 | 0.290 |
Alcohol,N(%) | 4578(73.9) | 1227(78.6) | 1177(75.3) | 1126(73.5) | 1048(68.4) | 43.968 | 0.000 |
HBP, N (%) | 2563(90.4) | 685(90.8) | 644(90.6) | 622(90.7) | 612(89.5) | 0.935 | 0.817 |
Diabetes,N(%) | 14.955 | 0.021 | |||||
Yes, N (%) | 990(15.2) | 259(15.9) | 230(14.1) | 216(13.3) | 285(17.5) | ||
No, N (%) | 5366(82.3) | 1331(81.6) | 1356(83.2) | 1378(84.5) | 1301(79.8) | ||
Borderline, N (%) | 166(2.5) | 42(2.6) | 44(2.7) | 36(2.2) | 44(2.7) | ||
Smoking, N (%) | 3.781 | 0.706 | |||||
Every day, N (%) | 1138(34.7) | 311(34.9) | 295(34.1) | 282(35.9) | 250(34.1) | ||
Some day, N (%) | 186(5.7) | 57(6.4) | 47(5.4) | 36(4.6) | 46(6.3) | ||
Not at all, N (%) | 1951(59.6) | 523(58.7) | 524(60.5) | 467(59.5) | 437(59.6) | ||
Vitamin D(nmol/L) | 64.40(46.60,81.50) | 64.40(46.15,82.15) | 64.5(48.40,82.10) | 65.00(47.45,82.73) | 62.20(44.80,78.85) | 12.935 | 0.005 |
Heart failure, N (%) | 179(2.8) | 60(3.7) | 50(3.1) | 35(2.1) | 34(2.1) | 10.913 | 0.012 |
coronary heart disease, N (%) | 260(4.0) | 78(4.8) | 69(4.2) | 54(3.3) | 59(3.6) | 5.506 | 0.138 |
Myocardial infarction, N (%) | 283(4.3) | 88(5.4) | 80(4.9) | 57(3.5) | 58(3.6) | 10.767 | 0.013 |