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Table 2 Echocardiographic parameters according to the sclerostin

From: Higher sclerostin is associated with pulmonary hypertension in pre-dialysis end-stage kidney disease patients: a cross-sectional prospective observational cohort study

Variables

Low Sclerostin

(< 218.18pmol/L)

n = 31

High Sclerostin

(≥ 218.18pmol/L)

n = 13

P

LVEDD (mm)

49.2 ± 7.2

54.6 ± 7.9

0.01

LVESD (mm)

31.9 ± 8.4

37.9 ± 9.3

0.01

SWT (mm)

10.4 ± 1.4

11.9 ± 2.2

0.04

PWT (mm)

10.5 ± 1.2

11.8 ± 2.3

0.04

LAVI (ml/m2)

32.0 ± 8.3

42.9 ± 14.3

< 0.01

LVMI (g/m2)

116.1 ± 31.9

152.1 ± 33.3

< 0.01

RWT (mm)

0.43 ± 0.1

0.45 ± 0.1

0.34

LVEF (%)

54.2 ± 10.2

47.3 ± 14.1

0.03

E (cm/s)

90.7 ± 97.8

83.2 ± 26.2

0.35

A (cm/s)

77.9 ± 24.0

77.9 ± 11.9

0.49

DT (ms)

205.8 ± 56.4

168.3 ± 29.0

0.02

e’ (cm/s)

6.9 ± 2.0

4.9 ± 1.7

< 0.01

a’ (cm/s)

9.0 ± 2.4

8.1 ± 2.0

0.11

s’ (cm/s)

6.9 ± 2.2

5.9 ± 1.8

0.08

RV s’ (cm/s)

11.2 ± 2.5

10.9 ± 2.3

0.35

E/e’ ratio

13.7 ± 12.4

17.7 ± 4.3

0.13

Estimated pulmonary artery systolic pressure (mmHg)

30.4 ± 6.7

44.2 ± 11.2

< 0.01

LV GLS

-15.0 ± 1.9

-15.33 ± 6.5

0.91

Pulmonary hypertension (> 35mmHg)

7(22.6%)

12(92.3%)

< 0.01

  1. Abbreviations LVEDD and LVESD, left ventricular end diastolic and systolic dimension; SWT and PWT, septal and posterior wall thickness; RWT, relative wall thickness; LVMI, left ventricular mass index; LAVI, left atrial volume index; EF, ejection fraction; e’ and a’, septal early and late mitral tissue velocity; s′, septal systolic mitral tissue velocity; E and A, early and late diastolic mitral inflow velocity; GLS, global longitudinal strain; DT, deceleration time