Fig. 1

COL4A1 expression patterns after clustering and causes of death. A The pattern of parameters from the image analysis describes the distribution and the appearance of COL4A1 expression. Higher intensity in red corresponds to higher value. B Numerical clinical parameters (not included in the clustering). Higher intensity in red corresponds to higher value. C Non-numerical clinical parameters (not included in the clustering). Green = yes, black = no, grey = no data. Group 1: mainly extracellular expression of COL4A1 (% area extracellular stained in tissue elevated). Group 2: general low expression of COL4A1. Group 3: mainly intracellular expression of COL4A1 (intracellular/extracellular area ratio is elevated). Group 4: both intracellular and extracellular expression (% area extracellular stained in tissue, % area intracellular stained in tissue, intracellular/extracellular area are elevated)