Fig. 3

The distribution of intra- and extracellular expression of COL4A1 in Group 1-4 and adult controls. Intracellular/extracellular stained area ratio, % area stained total in tissue, and % area intracellular stained in tissue were selected to visualize the separation of Group 1-4. A shows intensity levels and B area of intracellular staining. Group 1: mainly extracellular expression of COL4A1 (% area stained in tissue is low). Group 2: general low expression of COL4A1. Group 3: mainly intracellular expression of COL4A1 (high intracellular/extracellular area ratio). Group 4: both intracellular and extracellular expression occurs (all the parameters are increased). Adult controls had larger total stained area than all infants