Table 2 Results of signal detection for adverse events of anti-IL-5 drugs

Blood And Lymphatic System Disorders

Eosinophilia^a

328

20.67

5819.59

3.84

Gastrointestinal Disorders

Gastrooesophageal Reflux Disease

350

5.29

1204.78

2.01

General Disorders And Administration Site Conditions

Adverse Drug Reaction

298

3.33

482.35

1.33

Chest Discomfort^a

1271

15.05

16,068.74

3.65

Chest Pain

502

3.68

973.47

1.56

Chills

341

3.56

622.70

1.45

Condition Aggravated

1091

3.57

2024.68

1.62

Fatigue

1491

2.06

832.45

0.86

Ill-Defined Disorder

350

9.56

2617.90

2.83

Illness

539

2.89

665.60

1.23

Injection Site Pain

527

2.43

445.14

0.98

Malaise

1351

4.30

3416.87

1.90

Oedema Peripheral

279

3.77

564.38

1.49

Pyrexia

1040

3.51

1873.04

1.59

Secretion Discharge^a

250

21.57

4635.53

3.81

Therapeutic Product Effect Incomplete^a

3121

23.66

63,994.22

4.34

Immune System Disorders

Anaphylactic Reaction

249

5.41

884.83

1.97

Hypersensitivity

562

3.07

781.31

1.32

Infections And Infestations

Bronchitis

414

6.74

1990.83

2.38

Covid-19

499

2.13

298.28

0.78

Herpes Zoster

288

5.28

988.19

1.97

Infection

501

3.76

1008.76

1.59

Influenza

679

6.74

3272.32

2.46

Lower Respiratory Tract Infection^a

643

14.77

7951.78

3.53

Nasopharyngitis

947

5.86

3774.96

2.30

Pneumonia

2560

8.71

17,260.09

2.95

Respiratory Tract Infection^a

375

16.48

5223.38

3.58

Sinusitis

610

6.92

3040.83

2.48

Upper Respiratory Tract Infection

304

8.04

1837.83

2.56

Injury, Poisoning And Procedural Complications

Accidental Exposure To Product

453

4.42

1186.84

1.80

Exposure Via Skin Contact^a

490

120.58

43,858.25

5.93

Inappropriate Schedule Of Product Administration

776

2.87

946.59

1.27

Product Dose Omission Issue

2199

3.92

4828.04

1.81

Underdose

274

4.14

647.65

1.62

Wrong Technique In Device Usage Process

542

9.18

3861.21

2.85

Investigations

Blood Pressure Increased

446

3.14

646.44

1.32

Blood Test Abnormal^a

259

18.36

4054.03

3.62

Eosinophil Count Increased^a

560

78.66

35,435.09

5.56

Full Blood Count Abnormal^a

1922

60.09

96,236.90

5.49

Heart Rate Increased

282

3.41

478.38

1.35

Oxygen Saturation Decreased

279

5.05

896.95

1.90

Weight Increased

410

2.12

243.80

0.75

Musculoskeletal And Connective Tissue Disorders

Arthralgia

791

2.09

451.03

0.81

Back Pain

696

3.47

1218.45

1.52

Myalgia

420

3.07

584.62

1.28

Pain In Extremity

561

2.24

384.08

0.87

Nervous System Disorders

Headache

1582

2.90

1991.73

1.35

Product Issues

Product Complaint^a

515

12.17

5120.31

3.23

Psychiatric Disorders

Sleep Disorder

247

3.89

526.57

1.51

Sleep Disorder Due To A General Medical Condition^a

1766

189.72

219,426.83

6.69

Respiratory, Thoracic And Mediastinal Disorders

Asthma^a

8071

95.40

601,908.84

6.15

Asthmatic Crisis^a

486

172.80

56,633.75

6.23

Bronchiectasis^a

313

54.01

14,218.65

4.96

Chronic Obstructive Pulmonary Disease^a

554

13.09

5985.27

3.34

Cough^a

3162

12.62

33,004.38

3.48

Dysphonia

317

6.19

1357.85

2.21

Dyspnoea^a

6395

13.22

70,989.84

3.58

Dyspnoea Exertional^a

724

19.89

12,344.85

3.95

Lung Disorder

436

9.95

3421.92

2.93

Nasal Congestion^a

667

13.45

7429.47

3.41

Nasal Polyps^a

355

139.31

35,440.36

5.91

Obstructive Airways Disorder^a

1420

133.11

137,080.89

6.32

Oropharyngeal Pain

510

6.17

2178.26

2.29

Productive Cough^a

1413

32.38

39,585.24

4.68

Pulmonary Mass^a

291

19.70

4906.56

3.74

Respiratory Disorder^a

291

11.76

2779.49

3.07

Rhinorrhoea

463

7.44

2536.10

2.54

Sputum Discoloured^a

683

77.22

42,544.86

5.60

Upper-Airway Cough Syndrome^a

285

40.57

9917.96

4.61

Wheezing^a

4134

90.04

293,468.35

6.04

Skin And Subcutaneous Tissue Disorders

Rash

845

2.03

448.55

0.79

Urticaria

550

3.84

1146.86

1.63

Social Circumstances

Loss Of Personal Independence In Daily Activities^a

2492

39.39

84,484.01

4.99

Surgical And Medical Procedures

Hospitalisation

927

6.17

3974.32

2.37

Vascular Disorders

Hypertension

555

3.13

804.20

1.35