Table 1 Clinical characteristics of subjects with eePAP or less severe PH

No. (male/female)

29(26/3)

15(12/3)

14(14/0)

Age (y.o.)

73.4±6.37

72.80 ± 6.10

74.07 ± 6.82

0.67

Height (cm)

160.51 ± 7.76

161.54 ± 9.62

159.40 ± 5.24

0.26

Weight (kg)

53.54 ± 10.10

51.75 ± 11.11

55.46 ± 8.89

0.46

No. of patients with LTOT

16

8

7

0.84

Respiratory symptom and Activity

 mMRC score

1.97 ± 1.27

2.07 ± 1.28

1.86 ± 1.29

0.77

 SGRQ score

 Symptoms

52.48 ± 24.33

59.99 ± 25.64

44.43 ± 20.78

0.070

 Activity

52.74 ± 29.03

56.87 ± 28.11

48.33 ± 30.39

0.43

 Impact

30.03 ± 18.25

31.80 ± 16.73

28.13 ± 20.21

0.47

 Total

42.14 ± 20.72

45.41 ± 19.80

38.64 ± 21.84

0.47

SF36

 Physical functioning (PF)

66.38 ± 25.60

62.00 ± 27.70

71.07 ± 23.22

0.51

 Role physical (RP)

63.59 ± 28.25

57.09 ± 29.68

70.54 ± 25.88

0.26

 Bodily pain (BP)

73.83 ± 27.90

69.13 ± 29.46

78.86 ± 26.26

0.41

 General health (GH)

46.65 ± 13.03

47.92 ± 11.52

45.29 ± 14.80

0.86

 Vitality (VT)

56.06 ± 24.85

54.19 ± 27.00

58.06 ± 23.17

0.71

 Social functioning (SF)

70.26 ± 30.69

65.00 ± 33.47

75.89 ± 27.50

0.35

 Role emotional (RE)

62.20 ± 31.06

52.97 ± 27.66

71.43 ± 32.47

0.11

 Mental health (MH)

63.28 ± 23.23

63.67 ± 25.60

62.86± 21.37

0.69

TMET

 METS

3.53 ± 2.29

2.39 ±0.69

4.74 ± 2.78

0.064

6MWT

 6MWD

281.089 ± 127

258.57 ± 81.16

303.61 ± 161.60

0.65

Right heart cardiography

 mPAP (mmHg)

22.55 ± 5.24

23.87 ± 5.72

21.14 ± 4.47

0.12

 mPAPOE (mmHg)

37.34 ± 7.75

39.20 ± 8.69

35.36 ± 6.32

0.20

 mPAWP (mmHg)

6.72 ± 3.23

5.80 ± 2.93

7.71 ± 3.33

0.099

 mRVP (mmHg)

12.97 ± 3.27

13.53 ± 3.58

12.36 ± 2.90

0.23

 mRAP (mmHg)

4.48 ± 2.82

4.67 ± 3.02

4.29 ± 2.70

0.98

 CO (L/min)

4.19 ± 1.24

4.36 ± 1.31

4.01 ± 1.17

0.58

 CI (L/min/m²)

2.68 ± 0.71

2.80 ± 0.70

2.54 ± 0.73

0.34

 PVR (wood)

4.55 ± 3.52

5.55 ± 4.40

3.48 ± 1.88

0.11

Mixed venous

 PHv

7.39 ± 0.034

7.39 ± 0.040

7.39 ± 0.029

0.59

 PvCO₂ (mmHg)

48.57 ± 6.02

49.16 ± 4.24

47.93 ± 7.61

0.22

 PvO₂ (mmHg)

36.92 ± 2.59

36.49 ± 2.78

37.37 ± 2.38

0.33

 SVO₂ (%)

69.27 ± 4.39

68.52 ± 4.46

70.06 ± 4.35

0.73

PFT

 FEV1(L)

1.30 ± 0.67

1.23 ± 0.68

1.39 ±0.67

0.48

 FEV1%; FEV1/FVC(%)

48.61 ±20.13

48.57 ±24.21

48.65 ±15.54

0.57

 %FEV1; FEV1/pred FEV1(%)

65.34 ±37.44

60.75 ±37.33

70.26 ±38.31

0.45

 n (GOLD stage I/II/III/IV)

8/8/11/2

3/5/7/0

5/3/4/2

0.21

 %VC; VC/pred VC (%)

91.57 ±26.14

93.67 ±26.90

89.31 ±26.11

0.74

 %DLCO (%)

60.21% ± 32.18

56.84 ± 31.11

63.84 ± 34.18

0.68

TTE

 ET (msec)

272.5 ± 41.11

265.97 ± 32.03

279.50 ± 49.33

0.39

 PAAcT (msec)

97.45 ± 21.35

94.53 ± 17.83

100.57 ± 24.89

0.35

 AcT/ET

0.36 ± 0.064

0.36 ± 0.063

0.36 ± 0.067

0.82

 PEP (msec)

92.19 ± 21.82

95.37 ± 22.55

88.79 ± 21.30

0.40

 ICT (msec)

15.69 ± 19.60

18.60 ± 21.80

12.57 ±17.19

0.26

 IRT (msec)

69.47 ± 49.99

77.90 ± 59.31

60.43 ± 37.73

0.68

 TEI index

0.34 ± 0.23

0.40 ± 0.26

0.27 ± 0.17

0.21

 TAPSE (cm)

2.06 ± 0.47

2.05 ± 0.48

2.08 ± 0.47

0.89

 Diastolic RV area (cm²)

15.53 ± 4.09

15.11 ± 3.94

15.98 ±4.35

0.53

 Systolic RV area (cm²)

9.12 ± 2.46

8.57 ± 2.52

9.71 ± 2.33

0.21

 %FAC

60.81 ±14.39

63.29 ±14.99

58.14 ±13.76

0.31

Fractional Area Change (%)

Aortic Blood data at rest

 pH

7.42 ± 0.037

7.42 ± 0.034

7.42 ±0.041

0.98

 PCO₂ (mmHg)

40.67 ±5.51

41.96 ±4.14

39.28 ±6.54

0.17

 PO₂ (mmHg)

75.50 ± 12.65

72.24 ± 8.04

78.99 ± 15.80

0.13

 Aortic oxygen saturation (%)

94.39 ± 2.66

94.23 ± 1.44

94.56 ± 3.59

0.14

 BNP (pg/ml)

34.09 ± 28.25

35.00 ± 30.38

33.11 ± 26.88

1.00

 NT-proBNP (pg/ml)

138.55 ± 229.05

162.40 ± 283.52

113.00 ± 158.33

0.34

 LA (mg/dl)

9.92 ± 3.61

10.55 ±4.31

9.24 ± 2.66

0.39