Causal associations between gut microbiota, metabolites and asthma: a two-sample Mendelian randomization study

BMC Pulmonary Medicine

Table 1 Causal associations between gut microbiota and asthma by using the IVW method

Exposure	Outcome	Nsnp	Beta	SE	OR	95%CI	P
Class Actinobacteria	Asthma	15	−0.14	0.05	0.87	0.78–0.96	6.06 × 10⁻³
Class Bacilli	Asthma	18	−0.17	0.05	0.84	0.76–0.94	1.98 × 10⁻³
Family Pasteurellaceae	Asthma	14	−0.10	0.04	0.91	0.84–0.98	1.30 × 10⁻²
genus Butyricimonas	Asthma	13	0.14	0.06	1.16	1.03–1.29	1.26 × 10⁻²
Genus Lachnospiraceae_UCG001	Asthma	13	0.11	0.05	1.12	1.00–1.24	4.63 × 10⁻²
Genus Oxalobacter	Asthma	11	0.08	0.03	1.09	1.02–1.16	1.51 × 10⁻²
Genus Ruminococcus	Asthma	15	−0.11	0.05	0.90	0.81–0.99	3.02 × 10⁻²
Order Lactobacillales	Asthma	15	−0.18	0.06	0.83	0.74–0.94	1.92 × 10⁻³
Order NB1n	Asthma	13	0.07	0.03	1.08	1.01–1.15	3.51 × 10⁻²
Order Pasteurellales	Asthma	14	−0.10	0.04	0.91	0.84–0.98	1.30 × 10⁻²

IVW inverse-variance weighted: SNP single nucleotide polymorphism: Nsnp number of SNPs: SE standard error: OR odds ratio: CI confidence interval. P-values have undergone FDR correction, with the significance threshold at each taxonomic level calculated as 0.05 divided by the effective number of independent tests (phylum p = 0.05/9, class p = 0.05/16, order p = 0.05/20, family p = 0.05/35, and genus p = 0.05/131). P-values highlighted in bold denote significant associations, whereas non-bolded values indicate suggestive associations

ISSN: 1471-2466