Causal associations between gut microbiota, metabolites and asthma: a two-sample Mendelian randomization study

BMC Pulmonary Medicine

Table 2 Causal associations between asthma and gut microbiota by using the IVW method

Exposure	Outcome	Nsnp	Beta	SE	OR	95%CI	P
Asthma	Family Family_XIII	61	−0.05	0.02	0.95	0.91–0.99	2.60 × 10⁻²
Asthma	Genus Anaerofilum	59	0.10	0.04	1.10	1.02–1.19	1.56 × 10⁻²
Asthma	Genus Anaerostipes	61	−0.05	0.02	0.95	0.91–1.00	3.33 × 10⁻²
Asthma	genus Eubacterium_xylanophilum_group	60	−0.07	0.03	0.93	0.88–0.99	1.32 × 10⁻²
Asthma	Genus Family_XIII_UCG001	60	−0.07	0.03	0.93	0.89–0.98	5.54 × 10⁻³
Asthma	genus Intestinimonas	60	0.05	0.03	1.05	1.00–1.11	4.74 × 10⁻²
Asthma	Genus Lachnospiraceae_NK4A136_Group	61	−0.04	0.02	0.96	0.92–1.00	3.77 × 10⁻²
Asthma	Genus Lachnospiraceae_UCG004	60	0.05	0.02	1.05	1.01–1.11	2.92 × 10⁻²
Asthma	Genus Lachnospira	5	0.27	0.12	1.32	1.04–1.66	2.20 × 10⁻²
Asthma	Genus Marvinbryantia	60	−0.08	0.03	0.93	0.88–0.98	4.13 × 10⁻³
Asthma	Genus Ruminococcus_Torques_Group	61	−0.05	0.02	0.95	0.91–0.99	2.77 × 10⁻²

IVW inverse-variance weighted, SNP single nucleotide polymorphism, Nsnp number of SNPs, SE standard error, OR odds ratio, CI confidence interval. P-values have undergone FDR correction, with the significance threshold at each taxonomic level calculated as 0.05 divided by the effective number of independent tests (phylum p = 0.05/9, class p = 0.05/16, order p = 0.05/20, family p = 0.05/35, and genus p = 0.05/131). P-values highlighted in bold denote significant associations, whereas non-bolded values indicate suggestive associations

ISSN: 1471-2466