Table 4 Pre-defined clinical and functional outcome measures analyzed by different statistical approaches regarding the comparison “Triple always” versus “Triple not always”

SGRQ activity (score)

Estimate

9.625

3.197

1.835

2.611

95%CI

4.009; 14.685

-0.778; 7.172

-4.811; 8.481

-3.253; 8.476

p value

< 0.001

0.116

0.589

0.384

SGRQ impact (score)

Estimate

1.946

-0.357

-1.811

-0.728

95%CI

-2.753; 6.644

-4.960 4.245

-7.583; 3.961

-5.943; 4.488

p value

0.416

0.879

0.539

0.785

SGRQ symptoms (score)

Estimate

1.291

4.233e-01

-1.933

0.106

95%CI

-2.664; 5.246

-3.589; 4.454

-6.559; 2.692

-4.197; -4.409

p value

0.521

0.833

0.414

0.962

IPAQ (score)

Estimate

-281.629

245.720

-44.08

161.7

95%CI

-1318.311; 755.072

-819.705; 1311.145

-1249.088; 1160.928

-901.404; 1224.804

p value

0.593

0.652

0.943

0.766

6-MWD (m)

Estimate

-40.633

-9.252

-4.144

-8.116

95%CI

68.553; 12.715

-31.672; 13.166

-38.246; 29.958

-40.022; 23.791

p value

0.0045

0.419

0.812

0.619

EQ-VAS (score)

Estimate

-2.787

0.075

1.252

0.590

95%CI

-6.739; 1.163

-3.504; -3.655

-3.948; 6.452

-4.116; 5.295

p value

0.165

0.967

0.637

0.806

FVC /%predicted)

Estimate

-6.811

2.04e-01

-0.262

-0.019

95%CI

-11.048; -2.573

-0.621; 1.029

-11.202; 10.679

-4.616; 4.579

p value

0.002

0.627

0.919

0.994

ITGV (% predicted)

Estimate

9.625

-3.840

-5.342

-5.342

95%CI

0.269; 18.981

-8.352; 0.672

-16.136; 5.452

-16.136; 5.452

p value

0.044

0.097

0.333

0.333

PHQ9 (score)

Estimate

-0.724

-1.123

-1.555

-1.252

95%CI

-1.892; 0.444

-2.267; 0.020

-2.932; -0.179

-2.647; 0.142

p value

0.223

0.055

0.028

0.0796

CAT1 cough (score)

Estimate

-0.133

-0.116

-0.126

-0.097

95%CI

-0.372; 0.106

-0.360; 0.129

-0.418; 0.165

-0.383; 0.189

p value

0.274

0.354

0.396

0.506

CAT2 phlegm (score)

Estimate

0.054

0.008

-0.111

0.017

95%CI

-0.214; 0.322

-0.265; 0.282

-0.430; 0.208

-0.303; 0.337

p value

0.691

0.951

0.495

0.917

CAT3 chest tightness (score)

Estimate

-0.009

-0.129

-0.224

-0.187

95%CI

-0.313; 0.295

-0.429; 0.172

-0.580; 0.132

-0.522; 0.149

p value

0.953

0.402

0.219

0.276

CAT4 breathlessness (score)

Estimate

0.083

-0.077

-0.092

-0.070

95%CI

-0.127; 0.294

-0.262; 0.109

-0.335; -0.151

-0.298; 0.158

p value

0.437

0.418

0.46

0.549

CAT5 activity (score)

Estimate

0.300

0.018

-0.062

0.003

95%CI

-0.007; 0.608

-0.242; 0.278

-0.398; 0.273

-0.309; 0.316

p value

0.055

0.891

0.716

0.984

CAT6 confidence (score)

Estimate

0.254

-0.022

-0.247

-0.104

95%CI

-0.066; 0.574

-0.322; 0.277

-0.665; 0.172

-0.488; 0.281

p value

0.119

0.884

0.249

0.598

CAT7 sleep (score)

Estimate

-0.157

-0.080

-0.261

-0.210

95%CI

-0.495; 0.181

-0.526; 0.154

-0.627; 0.105

-0.552; 0.133

p value

0.361

0.284

0.164

0.231

CAT8 energy (score)

Estimate

-0.092

-0.139

-0.269

-0.150

95%CI

-0.338; 0.153

-0.373; 0.095

-0.545; 0.006

-0.424; 0.125

p value

0.459

0.245

0.056

0.285

CAT Sum (score)

Estimate

0.300

-0.642

-1.393

0.797

95%CI

-1.264;1.864

-2.094; 0.810

-3.276; 0.490

-2.586; 0.992

p value

0.706

0.387

0.148

0.383

PaCO₂ (mmHg)

Estimate

0.755

-0.335

-0.109

-0.252

95%CI

-0.422; 1.931

-1.406; 0.735

-1.383; 1.166

-1.456; 0.951

p value

0.207

0.540

0.867

0.681

PaO₂ (mmHg)

Estimate

-1.331

-0.380

-0.537

0.359

95%CI

-3.401; 0.739

-2.415; 1.655

-3.067; 1.994

-2.544; 1.827

p value

0.207

0.715

0.678

0.748

SaO₂ (%)

Estimate

-0.341

-0.052

0.073

-0.046

95%CI

-0.991; 0.308

-0.693; 0.588

-0.993; 0.846

-0.822; 0.729

p value

0.302

0.873

0.876

0.907