Fig. 1

Identification of 26 signature genes. The BH correction was used and the p-value was adjusted by controlling the FDR. (A) The volcano plot showed 2347 up-regulated (red) and 2444 down-regulated genes (blue) in the GSE28042 dataset (|log₂FC|>0, p.adj < 0.05). (B) The heatmap of the Idiopathic Pulmonary Fibrosis (IPF)-associated top 10 up- and down-regulated differentially expressed genes (DEGs). (C) The venn diagram of DEGs, Macrophage-related genes (MaRGs), and Mitochondria-related genes (MitoRGs). (D) The bubble plot of the the top 5 Gene Ontology (GO) Biological Process (BP) terms, GO Cellular Components (CC) terms, GO Molecular Function (MF) terms were enriched for 26 signature genes. (E) The column plot of the top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were enriched for 26 signature genes. (F) The Protein Protein Interaction (PPI) network including 26 signature genes. Nodes represent genes and colors represent Degree values, the redder the value, the stronger the gene’s role relationship in the network