Fig. 1

Differential gene analysis of chip GSE38974-GPL7723 and screening of candidate miRNAs associated with smoking COPD in the Vesiclepedia database. Note: (A) Volcano plot of miRNAs in chip GSE38974-GPL7723 (including 8 healthy controls who smoke and 19 COPD patients who smoke), with blue color indicating significantly down-regulated miRNAs and red color indicating significantly upregulated miRNAs; (B) Heatmap of differentially expressed miRNAs in chip GSE38974-GPL7723 (including 8 healthy controls who smoke and 19 COPD patients who smoke), with green color representing the normal group, purple color representing the disease group, red color indicating high expression, and blue color indicating low expression. The darker the color, the more significant the differential expression; (C) Venn diagram showing the intersection between the differential gene analysis results of chip GSE38974-GPL7723 and the search results in the Vesiclepedia database