Fig. 3

The core gene SPP1 is involved in the pathway screening of smoking-related COPD occurrence. Note: (A) Protein interaction network diagram of 64 candidate mRNAs, with darker colors indicating more associated molecules, with SPP1 being the darkest color; (B) Bubble plot of KEGG functional enrichment analysis results for SPP1-related genes, with redder colors indicating larger p-values and larger bubbles indicating more molecules included in the pathway. The x-axis represents the ratio of molecules; (C) The position and relationship of IL-17 A in the IL-17 signaling pathway; (D) the KEGG database was used to screen for genes related to SPP1 in the IL-17 signaling pathway (hsa04657); (E) Boxplot of the expression levels of SPP1, S100A9, MMP9, TNFAIP3, IL6, IL1B, MMP1, S100A8, and CCL20, where blue represents the normal control group, and red represents the smoking COPD group; (F) Correlation analysis plot of 8 genes related to SPP1 in the IL-17 signaling pathway