Fig. 2

CDF (Cumulative Distribution Function) plots showing baseline-to-week 26 changes in L-PF-35 Dyspnea domain scores for subgroups defined by anchor change, worse or not from baseline to week 26 (Panel A: UCSD anchor, Panel B: SGRQ Activity Domain anchor, Panel C: FVC% anchor, Panel D: DLCO% anchor) values. Footnote: Red = worsened according to anchor; Blue = not worsened (stable/improved) according to anchor; UCSD = University of California San Diego Shortness of Breath Questionnaire; SGRQ = St. George’s Respiratory Questionnaire; FVC% = percentage of the predicted forced vital capacity; DLCO% = percentage of the predicted diffusing capacity of the lung for carbon monoxide; L-PF = 35-item Living with Pulmonary Fibrosis Questionnaire. Definitions for anchors worsened: 1) ≥ 5 point increase for SGRQ Activity domain; 2) ≥ 5 point increase in UCSD score; 3) > 2% drop in FVC% (e.g., 70% to less than 68%); and 4) ≥ 5% drop in DLCO% (e.g., 70–65% or lower)