A first look at the reliability, validity and responsiveness of L-PF-35 dyspnea domain scores in fibrotic hypersensitivity pneumonitis

Table 4 Distribution of L-PF-35 Dyspnea change scores at week 26 for subjects who worsened or not according to each anchor

Anchor	N	Anchor Baseline Value Mean/Median	Difference in L-PF-35 Dyspnea Score from Baseline to 26 Weeks (Baseline minus 26 weeks; negative = worsened)
Anchor	N	Anchor Baseline Value Mean/Median	10th Percentile	25th Percentile	50th Percentile	75th Percentile	90th Percentile
UCSD
-Worse -Not	14 26	52.3 ± 19.2, 53.5 (34.0,74.0) 38.7 ± 28.1, 42.0 (11.0,60.0)	-52.4 -16.7	-24.4 -7.14	-12.5 0.0	2.4 4.2	17.9 10.7
SGRQa
-Worse -Not	20 20	61.9 ± 22.0, 66.2 (51.3,79.4) 59.4 ± 27.2, 69.9 (44.6,79.7)	-43.2 -12.2	-24.3 -2.2	-10.3 1.5	-1.8 8.3	2.1 25.6
FVC%
-Worse -Not	12 28	55.9 ± 11.4, 55.5 (50.0,59.0) 63.4 ± 11.5, 64.0 (59.0,67.5)	-52.4 -20.0	-30.2 -7.1	-17.5 0.0	-1.8 5.0	2.4 17.9
DLCO%
-Worse -Not	15 25	55.2 ± 11.1, 55.0 (48.0,66.0) 51.2 ± 16.8, 48.0 (40.0,58.0)	-52.4 -26.4	-21.4 -8.3	-4.2 0.0	0.0 5.8	4.2 17.6

FVC% = percentage of the predicted forced vital capacity; DLCO% = percentage of the predicted diffusing capacity of the lung for carbon monoxide; L-PF = 35-item Living with Pulmonary Fibrosis Questionnaire; SGRQa = St. George’s Respiratory Questionnaire Activity domain; UCSD = University of California San Diego Shortness of Breath Questionnaire

ISSN: 1471-2466