Table 2 Clinical and radiological comparisons between patients with and without ILA in the discovery cohort
| Â | No ILA | Â | ILA | Â | P value |
|---|---|---|---|---|---|
n | 202 | Â | 32 | Â | Â |
Age, y | 69.4 | ± 8.1 | 73.1 | ± 8.0 | 0.016 |
Sex, male | 185 | (91.6) | 30 | (93.8) | 0.945 |
BMI, kg/m2 | 21.9 | ± 2.8 | 22.7 | ± 3.4 | 0.155 |
Pack-years | 64.5 | ± 34.7 | 70.8 | ± 32.0 | 0.338 |
Smoking status, past | 150 | (74.3) | 27 | (84.4) | 0.309 |
mMRC, ≥2 | 47 | (23.3) | 11 | (34.4) | 0.258 |
FVC, L | 3.22 | ± 0.77 | 3.18 | ± 0.72 | 0.77 |
% predicted | 93.0 | ± 16.8 | 94.5 | ± 16.0 | 0.63 |
FEV1, L | 1.59 | ± 0.62 | 1.80 | ± 0.56 | 0.065 |
% predicted | 59.0 | ± 19.5 | 69.6 | ± 17.6 | 0.004 |
FEV1/FVC, % | 48. 8 | ± 13.0 | 56.3 | ± 10.7 | 0.002 |
DLCO, mL/min/mmHg | 13.2 | ± 5.2 | 11.1 | ± 4.5 | 0.03 |
% predicted | 60.1 | ± 21.8 | 52.1 | ± 20.1 | 0.054 |
Normal lungs, mL | 4175 | ± 997 | 3488 | ± 876 | < 0.001 |
ILD volume, mL | 51.1 | ± 37.2 | 114.1 | ± 76.6 | < 0.001 |
Ground-glass opacities, mL | 43 | ± 32 | 66 | ± 66 | 0.001 |
Reticulations, mL | 7.0 | ± 8. 5 | 37.6 | ± 30.0 | < 0.001 |
Consolidations, mL | 7.7 | ± 3.9 | 8.8 | ± 3.4 | 0.141 |
Honeycombing, mL | 1.0 | ± 1.7 | 10.0 | ± 18.9 | < 0.001 |
Nodules, mL | 5.7 | ± 4.9 | 11.7 | ± 9.6 | < 0.001 |
Hyperlucencies, mL | 821 | ± 1046 | 870 | ± 1058 | 0.806 |
Bronchi, mL | 76.7 | ± 19.8 | 89.7 | ± 17.3 | 0.001 |
Vessels, mL | 210 | ± 54 | 198 | ± 57 | 0.246 |