Table 3 Baseline characteristics of patients with COPD without ILAs at enrollment who subsequently developed ILAs and those who consistently showed no ILA findings on follow-up CT scans
| Â | Consistently without ILA | Â | new ILA | Â | P value |
|---|---|---|---|---|---|
n | 103 | Â | 8 | Â | Â |
Follow-up duration, y | 4.9 | ± 0.5 | 5.2 | ± 0.3 | 0.07 |
Age, y | 69.1 | ± 7.6 | 74.98 | ± 8.2 | 0.04 |
Sex, male | 94 | (91.3) | 8 | (100) | 0.842 |
BMI, kg/m2 | 21.8 | ± 2.7 | 23.8 | ± 1.5 | 0.035 |
Pack-years | 64.5 | ± 34.9 | 50.4 | ± 23.8 | 0.266 |
Smoking status, past | 74 | (71.8) | 6 | (75) | 1 |
mMRC, ≥2 | 27 | (26.2) | 2 | (25) | 1 |
FVC, L | 3.23 | ± 0.77 | 3.09 | ± 0.69 | 0.601 |
% predicted | 93.6 | ± 17.7 | 97.1 | ± 22.7 | 0.59 |
FEV1, L | 1.57 | ± 0.62 | 1.56 | ± 0.52 | 0.981 |
% predicted | 58.3 | ± 19.9 | 63.3 | ± 18.1 | 0.49 |
FEV1/FVC, % | 47.9 | ± 12.9 | 50.2 | ± 9.1 | 0.625 |
DLCO, mL/min/mmHg | 13.35 | ± 5.02 | 12.24 | ± 3.16 | 0.541 |
% predicted | 60.5 | ± 20. 7 | 61.2 | ± 18.8 | 0.929 |
Normal lungs, mL | 4226 | ± 897 | 3966 | ± 929 | 0.432 |
ILD volume, mL | 52.4 | ± 38.6 | 49.4 | ± 13.7 | 0.828 |
Ground-glass opacities, mL | 45.1 | ± 35.7 | 38.4 | ± 9.7 | 0.596 |
Reticulations, mL | 6.3 | ± 6.2 | 10.2 | ± 5.2 | 0.084 |
Consolidations, mL | 7.6 | ± 3.7 | 8.1 | ± 2.3 | 0.704 |
Honeycombing, mL | 1.0 | ± 1.7 | 0.86 | ± 1.3 | 0.802 |
Nodules, mL | 5.7 | ± 4.6 | 6.6 | ± 4.4 | 0.575 |
Hyperlucencies, mL | 808 | ± 994 | 599 | ± 674 | 0.561 |
Bronchi, mL | 76.8 | ± 20.8 | 74.2 | ± 17.2 | 0.739 |
Vessels, mL | 212.2 | ± 55.2 | 199.8 | ± 65.6 | 0.547 |