| ITT population | PP population | |||||
---|---|---|---|---|---|---|---|
Variables | Treatment | Time | Time | ||||
T3 | T6 | T12 | T3 | T6 | T12 | ||
Primary outcomes | |||||||
 ΔSGRQ | MT | -1.78 ± 0.30 | -2.23 ± 0.25 | -2.25 ± 0.42 | -1.79 ± 0.25 | -2.25 ± 0.34 | -2.29 ± 0.30 |
MT + ET | -1.25 ± 0.27 | -1.37 ± 0.41 | -1.30 ± 0.55 | -1.13 ± 0.20 | -1.39 ± 0.34 | -1.16 ± 0.54 | |
MT + RT | -1.53 ± 0.31 | -1.62 ± 0.34 | -1.73 ± 0.40 | -1.29 ± 0.28 | -1.37 ± 0.44 | -2.17 ± 0.48 | |
MT | 5.12 ± 2.01 | 6.05 ± 2.28 | 5.07 ± 2.74 | 5.05 ± 1.51 | 6.00 ± 2.07 | 4.99 ± 3.33 | |
 Δ3MWD(m) | MT + ET | 2.55 ± 1.61 | 13.28 ± 3.07* | 20.53 ± 2.58* a | 2.09 ± 1.49 | 13.23 ± 2.05* | 22.78 ± 3.29* a |
MT + RT | 3.12 ± 1.15 | 11.79 ± 2.38 | 14.74 ± 3.02 | 2.60 ± 1.59 | 12.13 ± 2.19 | 15.12 ± 3.50 | |
Secondary outcomes | |||||||
 ΔCAT | MT | -0.95 ± 0.25 | -1.81 ± 0.30 | -2.57 ± 0.53# | -0.96 ± 0.20 | -1.85 ± 0.28 | -2.79 ± 0.40# |
MT + ET | -0.72 ± 0.23 | -1.64 ± 0.45 | -1.96 ± 0.42 | -0.78 ± 0.15 | -1.56 ± 0.27 | -2.07 ± 0.36# | |
MT + RT | -0.78 ± 0.25 | -1.58 ± 0.29 | -2.01 ± 0.37# | -0.81 ± 0.22 | -1.64 ±0.34 | -2.25 ± 0.52# | |
MT | -0.08 ± 0.05 | -0.21 ± 0.09 | -0.27 ± 0.08 | -0.08 ± 0.03 | -0.20 ± 0.08 | -0.28 ± 0.10 | |
 ΔmMRC | MT + ET | -0.18 ± 0.05 | -0.39 ± 0.07 | -0.51 ± 0.05# | -0.24 ± 0.06 | -0.45 ± 0.08 | -0.57 ± 0.09# |
MT + RT | -0.20 ± 0.08 | -0.22 ± 0.09 | -0.24 ± 0.11 | -0.22 ± 0.06 | -0.25 ± 0.08 | -0.28 ± 0.10 | |
MT | 0.04 ± 0.17 | -0.15 ± 0.20 | -0.13 ± 0.25 | 0.04 ± 0.23 | -0.12 ± 0.26 | -0.11 ± 0.32 | |
 ΔHAD-A | MT + ET | -0.30 ± 0.18 | -0.42 ± 0.21 | -0.10 ± 0.15 | -0.38 ± 0.21 | -0.52 ± 0.23 | 0.05 ± 0.21 |
MT + RT | -0.16 ± 0.20 | 0.11 ± 0.16 | 0.35 ± 0.23 | 0.14 ± 0.23 | 0.20 ± 0.25 | 0.43 ± 0.31 | |
MT | -0.22 ± 0.30 | -0.37 ± 0.25 | -0.40 ± 0.20 | -0.23 ± 0.26 | -0.40 ± 0.30 | -0.41 ± 0.08 | |
 ΔHAD-D | MT + ET | -0.92 ± 0.31 | -1.26 ± 0.21 | -1.55 ± 0.25* # | -0.90 ± 0.26 | -1.24 ± 0.27 | -1.60 ± 0.29* # |
MT + RT | -0.45 ± 0.25 | -0.70 ± 0.30 | -0.98 ± 0.28 | -0.49 ± 0.30 | -0.70 ± 0.29 | -1.01 ± 0.32 | |
MT | 0.015 ± 0.03 | 0.038 ± 0.03 | 0.042 ± 0.03 | 0.015 ± 0.02 | 0.039 ± 0.02 | 0.045 ± 0.03 | |
 ΔFEV1(L) | MT + ET | 0.021 ± 0.02 | 0.065 ± 0.03 | 0.171 ± 0.03* | 0.020 ± 0.02 | 0.069 ± 0.02 | 0.176 ± 0.03* |
MT + RT | 0.025 ± 0.03 | 0.044 ± 0.02 | 0.090 ± 0.02 | 0.022 ± 0.02 | 0.043 ± 0.02 | 0.089 ± 0.03 | |
MT | 0.014 ± 0.02 | 0.024 ± 0.03 | 0.037 ± 0.01 | 0.015 ± 0.02 | 0.025 ± 0.02 | 0.037 ± 0.03 | |
 ΔFVC(L) | MT + ET | 0.020 ± 0.03 | 0.051 ± 0.02 | 0.158 ± 0.02* | 0.019 ± 0.02 | 0.047 ± 0.02 | 0.169 ± 0.03* |
MT + RT | 0.022 ± 0.02 | 0.055 ± 0.03 | 0.145 ± 0.02* | 0.020 ± 0.02 | 0.059 ± 0.02 | 0.152 ± 0.02* |