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Table 1 Physiological Response to Varying Mechanical Ventilation Strategies

From: Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion

Tidal Volume 6 ml/kg 12 ml/kg
PEEP 0 cmH2O 8 cmH2O 0 cmH2O 8 cmH2O
Heart rate (min-1) 214 ± 45 219 ± 26 211 ± 25 230 ± 31
MAP (mmHg) 63 ± 18 47 ± 7 65 ± 9 52 ± 7
Mean RVP (mmHg) 14 ± 2 14 ± 1 13 ± 2 15 ± 1
Cardiac output (L·min-1) 0.34 ± 0.02 0.23 ± 0.05 0.31 ± 0.05 0.25 ± 0.06
Peak PAW (cmH2O) 8 ± 1 16 ± 2 13 ± 1* 30 ± 5*
Plateau PAW (cmH2O) 7 ± 1 15 ± 2 12 ± 2* 27 ± 2*
Arterial pH 7.38 ± 0.10 7.38 ± 0.07 7.42 ± 0.04 7.43 ± 0.02
Arterial PO2 (torr) 69 ± 11 95 ± 6 69 ± 12 94 ± 11
Arterial PCO2 (torr) 42 ± 2 40 ± 5 41 ± 2 41 ± 1
A-aDO2 (torr) 19 ± 21 8 ± 9 25 ± 7 5 ± 8
  1. * p < 0.05 compared to other condition with same PEEP but different tidal volume; † p < 0.05 compared to other condition with different PEEP but same tidal volume. Mixed model used for statistical analysis with post-hoc comparisons using Tukey's HSD. Values presented are mean ± SD. MAP - mean arterial pressure, RVP - right ventricular pressure, PAW - airway pressure, A-aDO2 - alveolar-arterial oxygen difference.