|
Tidal Volume
|
6 ml/kg
|
12 ml/kg
|
|---|
|
PEEP
|
0 cmH2O
|
8 cmH2O
|
0 cmH2O
|
8 cmH2O
|
|---|
|
Heart rate (min-1)
|
214 ± 45
|
219 ± 26
|
211 ± 25
|
230 ± 31
|
|
MAP (mmHg)
|
63 ± 18
|
47 ± 7
|
65 ± 9
|
52 ± 7
|
|
Mean RVP (mmHg)
|
14 ± 2
|
14 ± 1
|
13 ± 2
|
15 ± 1
|
|
Cardiac output (L·min-1)
|
0.34 ± 0.02
|
0.23 ± 0.05†
|
0.31 ± 0.05
|
0.25 ± 0.06
|
|
Peak PAW (cmH2O)
|
8 ± 1
|
16 ± 2†
|
13 ± 1*
|
30 ± 5*†
|
|
Plateau PAW (cmH2O)
|
7 ± 1
|
15 ± 2†
|
12 ± 2*
|
27 ± 2*†
|
|
Arterial pH
|
7.38 ± 0.10
|
7.38 ± 0.07
|
7.42 ± 0.04
|
7.43 ± 0.02
|
|
Arterial PO2 (torr)
|
69 ± 11
|
95 ± 6†
|
69 ± 12
|
94 ± 11†
|
|
Arterial PCO2 (torr)
|
42 ± 2
|
40 ± 5
|
41 ± 2
|
41 ± 1
|
|
A-aDO2 (torr)
|
19 ± 21
|
8 ± 9
|
25 ± 7
|
5 ± 8†
|
- * p < 0.05 compared to other condition with same PEEP but different tidal volume; † p < 0.05 compared to other condition with different PEEP but same tidal volume. Mixed model used for statistical analysis with post-hoc comparisons using Tukey's HSD. Values presented are mean ± SD. MAP - mean arterial pressure, RVP - right ventricular pressure, PAW - airway pressure, A-aDO2 - alveolar-arterial oxygen difference.
