Skip to main content

Table 1 Physiological Response to Varying Mechanical Ventilation Strategies

From: Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion

Tidal Volume

6 ml/kg

12 ml/kg

PEEP

0 cmH2O

8 cmH2O

0 cmH2O

8 cmH2O

Heart rate (min-1)

214 ± 45

219 ± 26

211 ± 25

230 ± 31

MAP (mmHg)

63 ± 18

47 ± 7

65 ± 9

52 ± 7

Mean RVP (mmHg)

14 ± 2

14 ± 1

13 ± 2

15 ± 1

Cardiac output (L·min-1)

0.34 ± 0.02

0.23 ± 0.05†

0.31 ± 0.05

0.25 ± 0.06

Peak PAW (cmH2O)

8 ± 1

16 ± 2†

13 ± 1*

30 ± 5*†

Plateau PAW (cmH2O)

7 ± 1

15 ± 2†

12 ± 2*

27 ± 2*†

Arterial pH

7.38 ± 0.10

7.38 ± 0.07

7.42 ± 0.04

7.43 ± 0.02

Arterial PO2 (torr)

69 ± 11

95 ± 6†

69 ± 12

94 ± 11†

Arterial PCO2 (torr)

42 ± 2

40 ± 5

41 ± 2

41 ± 1

A-aDO2 (torr)

19 ± 21

8 ± 9

25 ± 7

5 ± 8†

  1. * p < 0.05 compared to other condition with same PEEP but different tidal volume; † p < 0.05 compared to other condition with different PEEP but same tidal volume. Mixed model used for statistical analysis with post-hoc comparisons using Tukey's HSD. Values presented are mean ± SD. MAP - mean arterial pressure, RVP - right ventricular pressure, PAW - airway pressure, A-aDO2 - alveolar-arterial oxygen difference.
Back to article page

BMC Pulmonary Medicine

ISSN: 1471-2466

Contact us