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  1. Research article

    The value of repeat radial-probe endobronchial ultrasound-guided transbronchial biopsy after initial non-diagnostic results in patients with peripheral pulmonary lesions

    Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be re...

    Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho and Chong-Jen Yu

    BMC Pulmonary Medicine 2017 17:132

    Published on: 17 October 2017

  2. Research article

    Effectiveness of pulmonary rehabilitation in patients with interstitial lung disease of different etiology: a multicenter prospective study

    Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported...

    Roberto Tonelli, Elisabetta Cocconcelli, Barbara Lanini, Isabella Romagnoli, Fabio Florini, Ivana Castaniere, Dario Andrisani, Stefania Cerri, Fabrizio Luppi, Riccardo Fantini, Alessandro Marchioni, Bianca Beghè, Francesco Gigliotti and Enrico M. Clini

    BMC Pulmonary Medicine 2017 17:130

    Published on: 10 October 2017

  3. Research article

    Chronic obstructive pulmonary disease, bronchial asthma and allergic rhinitis in the adult population within the commonwealth of independent states: rationale and design of the CORE study

    Main treatable Chronic Respiratory Diseases (CRDs) like Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma (BA) and Allergic Rhinitis (AR) are underdiagnosed and undertreated worldwide. CORE study was...

    Yuriy Feshchenko, Liudmila Iashyna, Damilya Nugmanova, Olga Gyrina, Marina Polyanskaya, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S. Pereira, Elcan Mammadbayov, Irada Akhundova and Averyan Vasylyev

    BMC Pulmonary Medicine 2017 17:131

    Published on: 10 October 2017

  4. Research article

    Association between dementia and discharge status in patients hospitalized with pneumonia

    Pneumonia is the most common cause of death in patients with dementia, but the outcomes of patients with dementia hospitalized with pneumonia are poorly understood. We sought to illuminate the association betw...

    Taisuke Jo, Hideo Yasunaga, Yusuke Sasabuchi, Nobuaki Michihata, Kojiro Morita, Yasuhiro Yamauchi, Wakae Hasegawa, Hideyuki Takeshima, Yukiyo Sakamoto, Hiroki Matsui, Kiyohide Fushimi and Takahide Nagase

    BMC Pulmonary Medicine 2017 17:128

    Published on: 6 October 2017

  5. Research article

    Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation

    Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure of the respiratory system. Our aim was to discriminat...

    Pablo Cruces, Sebastián González-Dambrauskas, Julio Quilodrán, Jorge Valenzuela, Javier Martínez, Natalia Rivero, Pablo Arias and Franco Díaz

    BMC Pulmonary Medicine 2017 17:129

    Published on: 6 October 2017

  6. Study protocol

    The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM)

    Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, le...

    Tao Wang, Gang Liu, Kun He, Xin Lu, Xianquan Liang, Meng Wang, Rong Zhu, Zongru Li, Feng Chen, Jun Ke, Qingming Lin, Chuanyun Qian, Bo Li, Jie Wei, Jingjun Lv, Li Li…

    BMC Pulmonary Medicine 2017 17:127

    Published on: 20 September 2017

  7. Research article

    A qualitative study to identify parents’ perceptions of and barriers to asthma management in children from South Asian and White British families

    Over one million children receive treatment for asthma in the UK. South Asian children experience excess morbidity and higher rates of hospitalization than the White population. This study aimed to explore per...

    Monica Lakhanpaul, Lorraine Culley, Noelle Robertson, Deborah Bird, Nicky Hudson, Narynder Johal, Melanie McFeeters, Emma Angell, Charlotte Hamlyn-Williams, Nadine Abbas, Logan Manikam and Mark Johnson

    BMC Pulmonary Medicine 2017 17:126

    Published on: 20 September 2017

  8. Research article

    Unmet needs in the treatment of idiopathic pulmonary fibrosis―insights from patient chart review in five European countries

    Two antifibrotic drugs, pirfenidone and nintedanib, are approved by the European Medicines Agency and the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF). In this analy...

    Toby M. Maher, Maria Molina-Molina, Anne-Marie Russell, Francesco Bonella, Stéphane Jouneau, Elena Ripamonti, Judit Axmann and Carlo Vancheri

    BMC Pulmonary Medicine 2017 17:124

    Published on: 15 September 2017

  9. Research article

    The effect of sedation and/or analgesia as rescue treatment during noninvasive positive pressure ventilation in the patients with Interface intolerance after Extubation

    Sedation and/or analgesia can relieve the patient-ventilator asynchrony. However, whether sedation and/or analgesia can benefit the clinical outcome of the patients with interface intolerance is still unclear.

    Yue-Nan Ni, Ting Wang, He Yu, Bin-Miao Liang and Zong-An Liang

    BMC Pulmonary Medicine 2017 17:125

    Published on: 15 September 2017

  10. Research article

    Clinical and radiological characteristics of patients with late-onset severe restrictive lung defect after hematopoietic stem cell transplantation

    Late-onset noninfectious pulmonary complications (LONIPCs), which occur more than 3 months after allogeneic hematopoietic stem cell transplantation (HSCT), are major causes of morbidity and mortality after tra...

    Ho Namkoong, Makoto Ishii, Takehiko Mori, Hiroaki Sugiura, Sadatomo Tasaka, Masatoshi Sakurai, Yuya Koda, Jun Kato, Naoki Hasegawa, Shinichiro Okamoto and Tomoko Betsuyaku

    BMC Pulmonary Medicine 2017 17:123

    Published on: 7 September 2017

  11. Research article

    Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males

    Inhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (< 100 nm) are likely candidates for triggering inflammatory responses and activa...

    Marieke Berger, Johannes D. de Boer, René Lutter, Michiel Makkee, Peter J. Sterk, Elles M. Kemper and Jaring S. van der Zee

    BMC Pulmonary Medicine 2017 17:121

    Published on: 6 September 2017

  12. Study protocol

    Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF) - a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial

    Pirfenidone is currently approved in the EU for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF) and offers a beneficial risk-benefit profile. However, there are several other, progressive...

    Jürgen Behr, Petra Neuser, Antje Prasse, Michael Kreuter, Klaus Rabe, Carmen Schade-Brittinger, Jasmin Wagner and Andreas Günther

    BMC Pulmonary Medicine 2017 17:122

    Published on: 6 September 2017

  13. Research article

    Propensity score analysis of lung cancer risk in a population with high prevalence of non-smoking related lung cancer

    Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. T...

    Kuei-Feng Lin, Hsiu-Fu Wu, Wei-Chun Huang, Pei-Ling Tang, Ming-Ting Wu and Fu-Zong Wu

    BMC Pulmonary Medicine 2017 17:120

    Published on: 6 September 2017

  14. Research article

    Reference Equations for the Six-Minute Walk Distance in the Healthy Chinese Han Population, Aged 18–30 Years

    The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity. However, there is a lack of standard reference equations for the six-minute walk distance (6...

    He Zou, Jia Zhang, Xiaoshu Chen, Yi Wang, Wei Lin, Jianfeng Lin, Hao Chen and Jingye Pan

    BMC Pulmonary Medicine 2017 17:119

    Published on: 29 August 2017

  15. Research article

    Influence of resting lung diffusion on exercise capacity in patients with COPD

    Lung diffusing capacity for carbon monoxide (DLCO) gives an overall assessment of functional lung surface area for gas exchange and can be assessed using various methods. DLCO is an important factor in exercis...

    Mehrdad Behnia, Courtney Wheatley, Alberto Avolio and Bruce Johnson

    BMC Pulmonary Medicine 2017 17:117

    Published on: 25 August 2017

  16. Research article

    Volatile organic compounds in ventilated critical care patients: a systematic evaluation of cofactors

    Expired gas (exhalome) analysis of ventilated critical ill patients can be used for drug monitoring and biomarker diagnostics. However, it remains unclear to what extent volatile organic compounds are present ...

    Tobias Hüppe, Dominik Lorenz, Mario Wachowiak, Felix Maurer, Andreas Meiser, Heinrich Groesdonk, Tobias Fink, Daniel I. Sessler and Sascha Kreuer

    BMC Pulmonary Medicine 2017 17:116

    Published on: 22 August 2017

  17. Study protocol

    Effect of counselling during pulmonary rehabilitation on self-determined motivation towards physical activity in people with chronic obstructive pulmonary disease – protocol of a mixed methods study

    Physical activity promotion in people with Chronic Obstructive Pulmonary Disease (COPD) is focus of research and public health. Patient-centred interventions like counselling are promising approaches to help p...

    Anne-Kathrin Rausch-Osthoff, Nicola Greco, Ariane Schwank, Swantje Beyer, David Gisi, Mandy Scheermesser, André Meichtry, Noriane Sievi, Thomas Hess and Markus Wirz

    BMC Pulmonary Medicine 2017 17:115

    Published on: 17 August 2017

  18. Research article

    FEV1 and FVC and systemic inflammation in a spinal cord injury cohort

    Systemic inflammation has been associated with reduced pulmonary function in individuals with and without chronic medical conditions. Individuals with chronic spinal cord injury (SCI) have clinical characteris...

    Jaime E. Hart, Rebekah Goldstein, Palak Walia, Merilee Teylan, Antonio Lazzari, Carlos G. Tun and Eric Garshick

    BMC Pulmonary Medicine 2017 17:113

    Published on: 15 August 2017

  19. Study protocol

    A multi-center randomized, controlled, open-label trial evaluating the effects of eosinophil-guided corticosteroid-sparing therapy in hospitalised patients with COPD exacerbations – The CORTICO steroid reduction in COPD (CORTICO-COP) study protocol

    The most commonly applied treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a 5-day course of high-dose systemic corticosteroids. However, this treatment has not been shown...

    Pradeesh Sivapalan, Mia Moberg, Josefin Eklöf, Julie Janner, Jørgen Vestbo, Rasmus Rude Laub, Andrea Browatzki, Karin Armbruster, Jon Torgny Wilcke, Niels Seersholm, Ulla Møller Weinreich, Ingrid Louise Titlestad, Helle Frost Andreassen, Charlotte Suppli Ulrik, Uffe Bødtger, Thyge Lynghøj Nielsen…

    BMC Pulmonary Medicine 2017 17:114

    Published on: 15 August 2017

  20. Research article

    Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer

    This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (N...

    Lei Zhao, Lai-Han Leung, Jing Wang, Huihui Li, Juanjuan Che, Lian Liu, Xiaojun Yao and Bangwei Cao

    BMC Pulmonary Medicine 2017 17:112

    Published on: 15 August 2017

  21. Research article

    Serological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features

    To identify the prognostic factors for survival in patients with interstitial pneumonia with autoimmune features (IPAF) who meet the serological domain of the IPAF criteria.

    Yuhei Ito, Machiko Arita, Shogo Kumagai, Reoto Takei, Maki Noyama, Fumiaki Tokioka, Keisuke Nishimura, Takashi Koyama, Kenji Notohara and Tadashi Ishida

    BMC Pulmonary Medicine 2017 17:111

    Published on: 14 August 2017

  22. Research article

    Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker

    Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnove...

    S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming and M. A. Karsdal

    BMC Pulmonary Medicine 2017 17:110

    Published on: 9 August 2017

  23. Research article

    Diagnostic value of medical thoracoscopy in malignant pleural effusion

    Medical thoracoscopy has been shown to be an efficacious procedure in diagnosing unexplained exudative pleural effusions with excellent safety. This study aimed to assess the diagnostic significance of thoraco...

    Yan-Bing Wu, Li-Li Xu, Xiao-Juan Wang, Zhen Wang, Jun Zhang, Zhao-Hui Tong and Huan-Zhong Shi

    BMC Pulmonary Medicine 2017 17:109

    Published on: 4 August 2017

  24. Research article

    Prognostic nomogram for inpatients with asthma exacerbation

    Asthma exacerbation may require a visit to the emergency room as well as hospitalization and can occasionally be fatal. However, there is limited information about the prognostic factors for asthma exacerbatio...

    Wakae Hasegawa, Yasuhiro Yamauchi, Hideo Yasunaga, Hideyuki Takeshima, Yukiyo Sakamoto, Taisuke Jo, Yusuke Sasabuchi, Hiroki Matsui, Kiyohide Fushimi and Takahide Nagase

    BMC Pulmonary Medicine 2017 17:108

    Published on: 4 August 2017

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