Normal BMI | Overweight | Obese | ANOVA | |
---|---|---|---|---|
n = 88 | n = 95 | n = 78 | p-value | |
Age, years | 66.0 ± 9.4 | 65.7 ± 8.2 | 65.4 ± 8.0 | NS |
Sex, % of men | 56 | 61 | 59 | NS |
Body mass index, kg/m2 | 22.3 ± 1.8* | 27.5 ± 1.5* | 35.1 ± 3.5 | <0.001 |
Height (cm) | 164 ± 9.1 | 165 ± 9.2 | 163 ± 9.8 | NS |
Weight (kg) | 61 ± 8.6* | 75 ± 9.8* | 91 ± 14.6 | <0.001 |
BODE score | 3.9 ± 2.0* | 3.1 ± 2.0 | 3.2 ± 2.4 | 0.002 |
Pulmonary function | ||||
FEV1, L | 1.02 ± 0.39* | 1.18 ± 0.42 | 1.14 ± 0.38 | 0.002 |
% predicted | 42 ± 15* | 49 ± 15 | 49 ± 17 | 0.002 |
FVC, L | 2.7 ± 0.8 | 2.6 ± 0.8 | 2.5 ± 0.9 | NS |
% predicted | 86 ± 22 | 83 ± 21 | 82 ± 23 | NS |
FEV1/FVC, % | 40 ± 10* | 45 ± 12* | 49 ± 12 | 0.001 |
FRC, L | 5.0 ± 1.6† | 4.4 ± 1.5 | 4.1 ± 1.7 | <0.001 |
% predicted | 159 ± 42† | 142 ± 41 | 135 ± 45 | <0.001 |
RV, L | 4.2 ± 1.4* | 3.6 ± 1.4 | 3.5 ± 1.5 | 0.002 |
% predicted | 178 ± 60* | 157 ± 58 | 151 ± 64 | 0.006 |
TLC, L | 6.8 ± 1.7* | 6.3 ± 1.7 | 6.1 ± 1.8 | 0.01 |
% predicted | 121 ± 22* | 112 ± 21 | 110 ± 23 | 0.001 |
IC, L | 1.8 ± 0.6 | 2.0 ± 0.6 | 2.0 ± 0.6 | NS |
% predicted | 73 ± 21 | 77 ± 20 | 81 ± 19 | NS |
IC/TLC, % | 28 ± 8* | 32 ± 9 | 33 ± 8 | <0.001 |
Incremental exercise test | ||||
Peak , L·min-1 | 0.85 ± 0.29* | 1.02 ± 0.32* | 1.12 ± 0.40 | 0.02 |
Peak , % predicted | 61 ± 36* | 75 ± 56* | 87 ± 69 | 0.01 |
Peak work capacity, Watt | 59 ± 22 | 69 ± 29 | 65 ± 29 | NS |
Peak work capacity, % predicted | 57 ± 28 | 64 ± 41 | 64 ± 37 | NS |
Constant exercise test | ||||
CET time, s | 367 ± 230 | 324 ± 201 | 338 ± 203 | NS |
6-minute walking test | ||||
6MWT, m | 407 ± 75 | 391 ± 78 | 342 ± 79* | 0.001 |
Work-walk, m·kg | 23296 ± 5902* | 29590 ± 8045* | 32779 ± 11078* | <0.001 |
Quality of life | ||||
SGRQ total score | 45 ± 17 | 45 ± 16 | 45 ± 18 | NS |
SGRQ symptoms score | 53 ± 23 | 51 ± 22 | 50 ± 24 | NS |
SGRQ activity score | 65 ± 20 | 65 ± 20 | 65 ± 22 | NS |
SGRQ impact score | 32 ± 18 | 32 ± 17 | 32 ± 19 | NS |
Pulmonary rehabilitation | ||||
Duration of rehabilitation (weeks) | 8.5 ± 1.7 | 8.5 ± 1.7 | 8.4 ± 1.7 | NS |
Home based rehabilitation, n (%) | 23 (26) | 27 (28) | 21 (27) | NS |