Figure 1

Schematic of study strategy to test whether pro-inflammatory endogenous ligands are generated during mechanical ventilation: (A) experiment#1 - evaluation of MyD88-dependent signaling during mechanical ventilation and TLR3 activation in WT and MyD88-/- mice; (B) experiment#2 - evaluation of TLR4-dependent signaling during mechanical ventilation and TLR3 activation in WT and TLR4-/- mice.