Skip to main content

Table 2 Clinical outcomes after atorvastatin treatment or placebo

From: Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial

Variables Baseline 4 weeks †Treatment difference,
atorvastatin minus
placebo (95% CI)
8 weeks †Treatment difference,
atorvastatin minus
placebo (95% CI)
  Atorvastatin
(n = 36)
Placebo
(n = 32)
Atorvastatin
(n = 34)
Placebo
(n = 30)
  Atorvastatin & ICS
(n = 33)
Placebo & ICS
(n = 27)
 
Morning PEF L/min 381.33
(138.79)
348.99
(116.49)
376.39
(141.63)
357.65
(121.38)
-10.67
(-38.70, 17.37)
p = 0.449
390.51
(123.38)
354.64
(123.70)
10.68
(-20.29, 41.65)
p = 0.492
Evening PEF L/min 391.9
(137.1)
375.8
(118.4)
384.8
(137.1)
367.4
(117.2)
4.95
(-18.61, 28.51)
p = 0.676
400.0
(140.1)
368.3
(130.5)
25.03
(-2.04, 52.11)
p = 0.069
FEV 1 pre-salbutamol, L 2.76
(0.91)
2.51
(0.76)
2.79
(0.83)
2.59
(0.74)
-0.01
(-0.13, 0.11)
p = 0.872
2.80
(0.89)
2.63
(0.76)
0.03
(-0.10, 0.16)
p = 0.651
FEV 1 post-salbutamol, L 3.08
(0.94)
2.88
(0.75)
3.02
(0.88)
2.89
(0.75)
-0.03
(-0.13, 0.07)
p = 0.492
3.02
(0.90)
2.93
(0.74)
-0.02
(-0.12, 0.07)
p = 0.642
PC 20 methacholine
geometric mean, mg/ml
3.29
(4.03)
2.15
(3.34)
4.12
(4.86)
2.93
(5.0)
1.36
(-1.29, 4.01)
p = 0.307
5.31
(6.2)
2.31
(4.0)
1.37
(-0.65, 3.40)
p = 0.179
ACQ Score
[6 questions]
1.86
(1.02)
1.86
(0.82)
1.42
(0.68)
1.91
(1.10)
-0.48
(-0.84,-0.12)
p = 0.009
1.29
(0.93)
1.64
(1.10)
-0.37
(-0.8,0.07)
p = 0.096
ACQ score
[7 questions]
1.88
(1.00)
1.96
(0.79)
1.50
(0.67)
1.90
(0.90)
-0.37
(-0.67, -0.07)
p = 0.016
1.38
(0.93)
1.77
(1.00)
-0.35
(-0.74, 0.04)
p = 0.081
AQLQ
Total score
5.36
(1.05)
5.14
(1.14)
5.71
(0.83)
5.04
(1.30)
0.52
(0.17, 0.87)
p = 0.005
5.79
(1.02)
5.27
(1.34)
0.37
(-0.02, 0.76)
p = 0.063
AQLQ Symptoms Domain 4.96
(1.08)
4.82
(1.20)
5.46
(0.90)
4.74
(1.39)
0.63
(0.18, 1.09)
p = 0.007
5.67
(4.96,6.34)
4.88
(3.91,6.5)
0.42
(-0.05, 0.89)
p = 0.082
AQLQ Activity Limitations Domain 5.84
(1.06)
5.52
(1.15)
5.99
(0.90)
5.36
(1.25)
0.40
(0.10, 0.71)
p = 0.010
6.08
(0.97)
5.58
(1.29)
0.31
(-0.01, 0.63)
p = 0.061
AQLQ Emotional Functions Domain 5.51
(1.36)
5.10
(1.35)
5.90
(1.19)
5.02
(1.62)
0.60
(0.10, 1.09)
p = 0.019
5.87
(1.39)
5.30
(1.62)
0.24
(-0.26, 0.74)
p = 0.335
AQLQ Environmental Stimuli Domain 5.10
(1.30)
5.09
(1.33)
5.41
(1.18)
5.07
(1.44)
0.34
(-0.09, 0.77)
p = 0.123
5.71
(1.15)
5.13
(1.47)
0.55
(0.07, 1.03)
p = 0.026
Reliever inhaler puffs per 24 hrs 3.19
(2.55)
2.94
(2.93)
2.58
(2.67)
3.97
(5.45)
-0.66
(-1.69, 0.37)
p = 0.205
2. 13
(2.63)
1.99
(2.33)
-0.12
(-1.35, 1.11)
p = 0.841
  1. Abbreviations: ACQ, Asthma Control Questionnaire; AQLQ, Asthma Quality of Life Questionnaire; PEF, peak expiratory flow rate; FEV1, forced expiratory volume in one second; Data represented as mean (SD) unless otherwise indicated.
  2. Treatment difference from analysis of covariance, analysing change from baseline and adjusting for baseline value.