Acute respiratory failure with one of the following condition: |
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1. SaO2 < 85% for at least 1 hour |
2. Oxygenation Index >25 for at least 6 hours after ventilation optimisation |
3. PaO2/FiO2 < 100 with PEEP ≥ 10cmH2O for at least 6 hours after ventilation's optimization |
4. Hypercapnia with pH < 7.25 |
5. SvO2 < 65% with hematocrit >30 and under vasoactive drugs infusion |