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Table 5 Sensitivity analysis for smokers: mean (SE) postbronchodilator FEV1 decline in ml/year in the three categories* based on alternative LLN prediction equations for the base case population

From: Lung function decline in relation to diagnostic criteria for airflow obstruction in respiratory symptomatic subjects

    Category*
   Non-obstructed Discordant Obstructed p-value
   (LLN-Fixed-) (LLN-Fixed+) (LLN+Fixed+) Overall difference
between categories
LLN-Fixed+ versus
LLN-Fixed-
LLN-Fixed+ versus
LLN+Fixed+
Swanney [6], 2008 FEV1 decline -21 (3) -21 (7) -50 (5) < 0.001 0.973 < 0.001
  n 578 138 292    
ECSC [25], 1993 FEV1 decline -22 (3) -24 (15) -50 (3) < 0.001 0.870 0.094
  n 578 29 452    
Kuster [28], 2008 FEV1 decline -20 (3) -8 (20) -48 (3) < 0.001 0.599 0.087
  n 563 14 557    
Falaschetti [26], 2004 FEV1 decline -21 (3) -21 (18) -47 (3) < 0.001 0.985 0.153
  n 546 24 542    
Brandli [27], 2000 FEV1 decline -21 (3) -4 (11) -49 (4) < 0.001 0.026 < 0.001
  n 575 60 397    
Hankinson [29], 1999 FEV1 decline -21 (3) -37 (22) -48 (3) < 0.001 0.468 0.620
  n 569 18 523    
  1. ECSC: European Community for Steel and Coal; FEV1: forced expiratory volume in 1 s; LLN: lower limit of normal; SD: standard deviation
  2. * based on reference equations for LLN as indicated in first column
  3. † between group differences were analyzed using random coefficient regression models with random intercept and random slope; adjustment for inhaled corticosteroid use
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