Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study

Table 3 Univariable associations, expressed as the antilogarithm (exp(β)) of the coefficient β, between continuous time dependent covariables and the natural logarithm of hs-cTnT (lnTnT) assessed using an ordinary least square linear regression model (OLS, index admission) and a linear mixed model (LMM, repeat admissions)

		Interindividual associations between covariables and lnTnT (OLS)		Intraindividual associations between covariables and lnTnT (LMM)
		Index admission in 99 patients		161 repeat admissions in 41 patients
Covariable	Change in covariable	exp(β) (95% CI)	p-value	exp(β) (95% CI)	p-value
MAP	+5 mmHg	1.002 (0.951 – 1.06)	0.944	1.003 (0.98 – 1.03)	0.792
Creatinine	+10 μmol/L	1.08 (1.03 – 1.14)	0.004	1.10 (1.04 – 1.16)	0.0004
CRP	+10 mg/L	1.01 (0.97 – 1.05)	0.680	1.005 (0.99 – 1.02)	0.478
Neutrophil count	+5x10⁹/mL	0.93 (0.75 – 1.17)	0.555	1.005 (0.99 – 1.02)	0.468
Hemoglobin	+1 g/L	0.96 (0.85 – 1.08)	0.477	1.03 (0.68 – 1.6)	0.902
Heart rate	+5 bpm	0.98 (0.94 – 1.02)	0.392	1.02 (0.998 – 1.04)	0.078
PaCO₂*	+1 kPa	1.09 (0.96 – 1.24)	0.195	1.05 (0.98 – 1.12)	0.144
PaO₂*	+1 kPa	0.97 (0.87 – 1.08)	0.573	0.96 (0.94 – 0.99)	0.008

*Missing in eight admissions. OLS, ordinary least square linear regression model; LMM, linear mixed model; MAP, Mean arterial pressure; bpm, beats per minute.

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