Skip to main content

Table 2 Regression coefficients and odds ratios with 95% confidence intervals as derived from the original model and the internally validated model

From: A predictive tool for an effective use of 18F-FDG PET in assessing activity of sarcoidosis

 

Original model

Model after internal validation

Variable

Regression coefficient

Odds ratio (95% CI)

p-value

Regression coefficient*

Odds ratio (95% CI)

Intercept

-0.32

-

-

-0.23

-

Elevated sIL-2R levels

1.98

7.27 (1.86 – 28.40)

0.004

1.85

6.33 (1.73-28.17)

Total HRCT score

0.24

1.27 (1.06 - 1.52)

0.011

0.22

1.25 (1.04-1.50)

To calculate the absolute risk of a positive PET result:

P(PET-positive) = (1 / (1 + exp(-(-0.23 + 1.85 * sIL-2R + 0.22 * HRCT score)))) * 100%

  1. CI: confidence interval; sIL-2R: soluble interleukin-2 Receptor; HRCT: high-resolution computed tomography; PET: positron emission tomography.
  2. * Regression coefficients after adjustment for overfitting by shrinkage (shrinkage factor = 0.93); the intercept was re-estimated.