Noninvasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease and hypercapnic encephalopathy

Briones Claudett, Killen Harold; Briones Claudett, Monica; Chung Sang Wong, Miguel; Nuques Martinez, Alberto; Soto Espinoza, Ricardo; Montalvo, Mayra; Esquinas Rodriguez, Antonio; Gonzalez Diaz, Gumersindo; Grunauer Andrade, Michelle

doi:10.1186/1471-2466-13-12

Table 2 Evolution of blood gases, vital signs, and ventilatory parameters (mean ± SD)

From: Noninvasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease and hypercapnic encephalopathy

Variables	Groups	Initial	1 hour	3 hours	12 hours	P
GSC	BiPAP S/T	8.3 ± 1.4	9.7 ± 2	12 ± 1.5	13 ± 1	.00001*
GSC	BiPAP S/T + AVAPS	8.3 ± 1.6	11 ± 1	14.1 ± 0.8	15 ± 0	.00001*
pH	BiPAP S/T	7.28 ± 0.02	7.30 ± 0.05	7.31 ± 0.11	7.32 ± 0.12	.31
pH	BiPAP S/T + AVAPS	7.29 ± 0.03	7.34 ± 0.04	7.37 ± 0.11	7.37 ± 0.08	.31
pCO ₂	BiPAP S/T	64.8 ± 9.1	58.3 ± 8.7	53.2 ± 9	50.1 ± 6.5	.03*
pCO ₂	BiPAP S/T + AVAPS	63 ± 16.3	50.7 ± 11.2	45.4 ± 7.9	43.6 ± 6.5	.03*
PO ₂	BiPAP S/T	66.6 ± 12.7	83.1 ±17.8	75.3 ± 26.7	79.7 ± 16.2	.31
PO ₂	BiPAP S/T + AVAPS	71.5 ± 16.8	78 ± 19.1	87.5 ± 11.5	87.4 ± 18	.31
HCO ₃	BiPAP S/T	26.9 ± 5.7	24.4 ± 6.3	25.8 ± 4.6	27.1 ± 4.3	.19
HCO ₃	BiPAP S/T + AVAPS	24.4 ± 5	22.5 ± 3.5	23.7 ± 5.2	24.6 ± 4.3	.19
Base excess	BiPAP S/T	3.3 ± 6.9	0.1 ± 7	10.3 ± 31.7	3.6 ± 4.7	.06
Base excess	BiPAP S/T + AVAPS	−1.8 ± 5.7	2.8 ± 18	5.7 ± 19.8	2.9 ± 9	.06
Systolic blood pressure	BiPAP S/TS/T	125.1 ± 10	124.2 ± 12.6	130.4 ± 14.3	130.6 ± 13.8	.29
Systolic blood pressure	BiPAP S/T + AVAPS	125.9 ± 17.3	131.1 ± 21.1	129.9 ± 18.4	123.5 ± 16.9	.29
Diastolic blood pressure	BiPAP S/T	73.9 ± 9.8	72.2 ± 8.4	71.8 ± 9.4	73.7 ± 10.7	.07
Diastolic blood pressure	BiPAP S/T + AVAPS	65.5 ± 11.6	69.8 ± 11.6	70.1 ± 11.1	65.9 ± 8.5	.07
Heart rate	BiPAP S/T	86.7 ± 9.1	82.1 ± 7.8	80.4 ± 5.8	79.1 ± 5.5	.07
Heart rate	BiPAP S/T + AVAPS	82 ± 10.9	82.5 ± 9.9	72.8 ± 14.1	72. ± 11.2	.07
Respiratory rate	BiPAP S/T	27.9 ± 5.6	23.2 ± 3.5	21 ± 2.6	20 ± 1.61	.01*
Respiratory rate	BiPAP S/T + AVAPS	29 ± 6.9	17.4 ± 3.2	18.5 ± 3.6	19.9 ± 5.1	.01*
Maximum delivered IPAP received	BiPAP S/T	12.3 ± 0.9	12.6 ± 0.9	14.3 ± 0.8	14.7 ± 1	.005*
Maximum delivered IPAP received	BiPAP S/T + AVAPS	19.8 ± 2.2	18.3 ± 2.3	18 ± 2.6	17 ± 2.3	.005*
EPAP	BiPAP S/T	5.9 ± 0.3	6 ± 0	6 ± 0	6 ± 0	.32
EPAP	BiPAP S/T + AVAPS	6 ± 0	6 ± 0	5.9 ± 0.3	5.9 ± 0.3	.32
Minute volume	BiPAP S/T	8.7 ± 3.1	9.2 ± 2.2	10.8 ± 1.4	10.6 ± 1.4	.17
Minute volume	BiPAP S/T + AVAPS	8.5 ± 2.2	10.5 ± 2.5	11.5 ± 3.1	11.6 ± 1.8	.17
Exhaled tidal volume	BiPAP S/T	304 ± 60.6	400.5 ± 73.9	519 ± 61.4	531.1± 63.6	.01*
Exhaled tidal volume	BiPAP S/T + AVAPS	298.6 ± 54.3	606.3 ± 75.4	626.3 ± 77.6	617.6 ± 77.4	.01*
Leak	BiPAP S/T	9.3 ± 3.8	21 ± 2	11 ± 3	11 ± 3.4	.20
Leak	BiPAP S/T + AVAPS	14 ± 11.2	18.3 ± 3.7	17.5 ± 16	17.5 ± 16	.20

*Statistically significant (P value <.05).
^**The ANOVA with repeated measures to compare the ability of different variables the both groups at 1, 3, 12 hours.

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