Figure 2
From: Increased incidence of autoimmune markers in patients with combined pulmonary fibrosis and emphysema
Presence of CD20+ B cells within the fibrotic interstitium in patients with CPFE. Representative immunohistochemistry with a CD20 antibody on lung paraffin sections from patients with CPFE with a UIP histopathologic pattern and controls. As illustrated clusters of CD20+ B cells forming lymphoid follicles were found within the fibrotic interstitium in areas adjacent to fibroblastic foci in CPFE patients with ANA + profile (a, b) as well as CPFE patients with ANCA + profile (c, c), whereas CD20+ cells were almost absent in biopsy samples from patients with CPFE and negative ANCA and ANA profile (e, f), as well as in control lung samples (g, h). Original magnification : ×200 (a, c, e and g), × 400 (b, d, f and h).