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Table 3 Serum immunologic profile and clinical symptoms in study population at time of diagnosis

From: Increased incidence of autoimmune markers in patients with combined pulmonary fibrosis and emphysema

Variable

CPFE

IPF

 

Number (n) – frequency (%)

Number (n) – frequency (%)

Total number

40

60

ANA

17 (42.5)*

16 (26.7)

Anti-ds DNA

0

2 (3.3)

Anti-Ro (SSa)

0

0

Anti-La (SSb)

0

0

p-ANCA (MPO)

7 (17.5)*

0

c-ANCA

0

0

RF

3 (7.5)

6 (10)

Anti-CCPs

2 (5)

4 (6.6)

Anti-scl 70

1 (2.5)

2 (3.3)

Renal biopsy consistent of MPA

3 (7.5)

NA

Arthralgia

3 (7.5)

6 (10)

Morning Stiffness

2 (5)

6 (10)

Raynaud’s phenomenon

4 (10)

2 (3.3)

Dysphagia

1 (3)

2 (3.3)

Hemoptysis

2 (5)

0

Hematuria

7 (17.5)*

0

  1. Abbreviations: ANA: anti-nuclear antibodies, ANCA: antineutrophil cytoplasm antibodies (ANCAs), anti-CCPs: anti cyclic citrullinated peptide antibodies, anti-ds DNA: anti-double strand DNA antibodies, anti-scl 70: anti-topoisomerase I antibodies, IPF: Idiopathic Pulmonary Fibrosis, MPA: Microscopic Polyangiitis, MPO: myeloperoxidase, RF: rheumatoid factor, *p < 0.05.