Table 4 Distribution of TIMP2, TGFB1, MMP9, and TNF genotypes according to the existence and severity of emphysema changes
Emphysema phenotype | Genotype | No radiologic changes* | Radiologic changes | OR (95% CI)† | Subnormal‡ changes | OR (95% CI)† | Pathological§ changes | OR (95% CI)† |
|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | |||||
All | TIMP2 rs2277698 | |||||||
G/G | 462 (77.9) | 270 (77.8) | 1.0 | 180 (79.6) | 1.0 | 90 (74.4) | 1.0 | |
G/A or A/A | 131 (22.1) | 77 (22.2) | 1.02 (0.72-1.44) | 46 (20.4) | 0.92 (0.62-1.38) | 31 (25.6) | 1.35 (0.83-2.22) | |
Centrilobular | TGFB1 rs2241718 | |||||||
G/G | 518 (72.8) | 173 (77.6) | 1.0 | 74 (71.2) | 1.0 | 99 (83.2) | 1.0 | |
G/A or A/A | 194 (27.2) | 50 (22.4) | 0.76 (0.52-1.11) | 30 (28.8) | 1.08 (0.68-1.73) | 20 (16.8) | 0.53 (0.30-0.90) | |
MMP9 rs3918242 | ||||||||
C/C | 519 (72.5) | 171 (75.7) | 1.0 | 74 (70.5) | 1.0 | 97 (80.2) | 1.0 | |
C/T or T/T | 197 (27.5) | 55 (24.3) | 0.77 (0.53-1.12) | 31 (29.5) | 1.08 (0.68-1.72) | 24 (19.8) | 0.51 (0.30-0.86) | |
Paraseptal | TIMP2 rs2277698 | |||||||
G/G | 609 (78.9) | 123 (73.2) | 1.0 | 72 (78.3) | 1.0 | 51 (67.1) | 1.0 | |
G/A or A/A | 163 (21.1) | 45 (26.8) | 1.41 (0.94-2.13) | 20 (21.7) | 1.04 (0.59-1.81) | 25 (32.9) | 1.94 (1.14-3.30) | |
TNF rs1800629 | ||||||||
G/G | 605 (78.3) | 111 (66.1) | 1.0 | 61 (66.3) | 1.0 | 50 (65.8) | 1.0 | |
G/A or A/A | 168 (21.7) | 57 (33.9) | 2.03 (1.38-2.98) | 31 (33.7) | 2.12 (1.30-3.48) | 26 (34.2) | 2.10 (1.24-3.56) |