Skip to main content

Table 5 Distribution of MMP9/TGFB1 combined genotypes according to the existence and severity of centrilobular changes

From: Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes

Genotype combination (MMP9rs3918242-TGFB1rs2241718) No radiologic changes* Radiologic changes OR (95% CI) Subnormal changes OR (95% CI) Pathological§ changes OR (95% CI)
n (%) n (%)   n (%)   n (%)*  
Wild type-wild type # 375 (52.8) 130 (58.3) 1.0 52 (50.0) 1.0 78 (65.5) 1.0
Heterozygote/ homozygote + 281 (39.6) 81 (36.3) 0.83 (0.60-1.15) 43 (41.3) 1.07 (0.69-1.68) 38 (31.9) 0.66 (0.43-1.02)
Heterozygotes or homozygotes ± 54 (7.6) 12 (5.4) 0.63 (0.36-1.09) 9 (8.7) 1.29 (0.68-2.46) 3 (2.5) 0.22 (0.08-0.61)
  1. *Reference category.
  2. Adjusted for age, sex, pack-years and years of asbestos exposure.
  3. The changes were considered as subnormal if the emphysema subtype score was < 1 (< 2 in emphysema sum score).
  4. §The changes were considered as pathological if the emphysema subtype score was ≥ 1 (≥ 2 in emphysema sum score).
  5. # MMP9 CC/TGFB1 GG.
  6. + MMP9 CT/TGFB1 GG or MMP9 CC/TGFB1 GA.
  7. ± MMP9 CT/TGFB1 GA or MMP9 TT or TGFB1 AA.